Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 5/20 | 0.52 |
| ▸ | CASR | P41180 | 1/20 | 0.46 |
| ▸ | DHFR | P00374 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6309838 | 0.86 | CASR (0.53) | GHSRCASRPDE4APDE4BPDE4C | |
| SCHEMBL6313515 | 0.86 | GHSR (0.50) | GHSRMEN1KMT2A | |
| SCHEMBL6309040 | 0.86 | PDE4A (0.56) | GHSRCASRMEN1KMT2APDE4A | |
| SCHEMBL6308411 | 0.82 | DHFR (0.49) | DHFRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6307779 | 0.81 | EGFR (0.57) | CASRMEN1KMT2A | |
| SCHEMBL6307635 | 0.81 | EGFR (0.57) | GHSRCASRMEN1KMT2APDE4A | |
| SCHEMBL6394256 | 0.79 | EGFR (0.55) | GHSRCASRMEN1KMT2A | |
| SCHEMBL6313293 | 0.78 | CASR (0.52) | GHSRCASRDHFR | |
| SCHEMBL6308112 | 0.78 | KMT2A (0.50) | GHSRCASRKMT2A | |
| SCHEMBL5877934 | 0.77 | GHSR (0.41) | GHSRDHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6890930-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |
| EP-1216235-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023365-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |