Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.59 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.59 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.59 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.53 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CASR | P41180 | 2/20 | 0.47 |
| ▸ | F11 | P03951 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6313871 | 0.89 | KIF11 (0.51) | PDE4APDE4BPDE4CPDE4DTLR8 | |
| SCHEMBL6308411 | 0.88 | DHFR (0.49) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6309834 | 0.88 | PTGES (0.50) | PDE4APDE4BPDE4CPDE4DRAB9A | |
| SCHEMBL28206539 | 0.87 | PDE4A (0.75) | PDE4APDE4BPDE4CPDE4DRAB9A | |
| SCHEMBL6313964 | 0.85 | CYP1A2 (0.52) | PDE4APDE4BPDE4CPDE4DTLR8 | |
| SCHEMBL6309810 | 0.81 | ALDH1A1 (0.76) | RAB9APOLBALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL6306194 | 0.80 | ALDH1A1 (0.72) | RAB9APOLBALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL6306807 | 0.79 | ALDH1A1 (0.56) | PDE4APDE4BPDE4CPDE4DTLR8 | |
| SCHEMBL6309040 | 0.79 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DRAB9A | |
| SCHEMBL6308509 | 0.78 | ALDH1A1 (0.65) | RAB9AALDH1A1LMNASMN1; SMN2RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6890930-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |
| EP-1216235-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023365-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |