Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 8/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ANPEP | P15144 | 3/20 | 0.47 |
| ▸ | DPP4 | P27487 | 3/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6308700 | 1.00 | ESR1 (0.48) | ESR1MEN1KMT2AANPEPDPP4 | |
| SCHEMBL24710720 | 0.83 | ANPEP (0.51) | ESR1MEN1KMT2AANPEPDPP4 | |
| SCHEMBL10914223 | 0.83 | ANPEP (0.50) | ESR1MEN1KMT2AANPEPDPP4 | |
| SCHEMBL16487855 | 0.81 | ALDH1A1 (0.63) | MEN1KMT2AALDH1A1TDP1CYP2D6 | |
| SCHEMBL4626053 | 0.80 | TDP1 (0.59) | ALDH1A1TDP1GAAMAPTRAB9A | |
| SCHEMBL11914467 | 0.80 | TDP1 (0.59) | ALDH1A1TDP1GAAMAPTRAB9A | |
| SCHEMBL22893524 | 0.80 | TDP1 (0.42) | MEN1KMT2AALDH1A1TDP1NPC1 | |
| SCHEMBL9933904 | 0.80 | TDP1 (0.59) | ALDH1A1TDP1GAAMAPTRAB9A | |
| SCHEMBL21976969 | 0.79 | ANPEP (0.55) | ESR1MEN1KMT2AANPEPDPP4 | |
| SCHEMBL16487856 | 0.77 | TDP1 (0.36) | MEN1KMT2AALDH1A1TDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6903095-B2 | Nitrogen compounds such as 2-(5-(4-Fluoro-benzyloxy)-1,3-dioxo -1,3-dihydro-isoindol-2-yl)-acetamide, used for prophylaxis of Alzheimer's disease; amine oxidase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2005-06-07 | — | — | US | disclosed |
| EP-1490334-A1 | PHTHALIMIDO DERIVATIVES AS INHIBITORS OF MONOAMINE OXIDASE B | F. HOFFMANN-LA ROCHE AG (CH) | 2004-12-29 | — | — | EP | disclosed |
| US-20040229871-A1 | Phthalimido derivatives and a process for their preparation | CESURA ANDREA (CH) | 2004-11-18 | — | — | US | disclosed |
| US-6660736-B2 | MAO-B inhibitors | HOFFMANN-LA ROCHE INC. | 2003-12-09 | — | — | US | disclosed |
| US-20030195208-A1 | PHTHALIMIDO DERIVATIVES AND A PROCESS FOR THEIR PREPARATION | HOFFMANN-LA ROCHE INC. | 2003-10-16 | — | — | US | disclosed |
| WO-2003080573-A1 | PHTHALIMIDO DERIVATIVES AS INHIBITORS OF MONOAMINE OXIDASE B | F. HOFFMANN-LA ROCHE AG (CH) | 2003-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030195208-A1 | PHTHALIMIDO DERIVATIVES AND A PROCESS FOR THEIR PREPARATION | MAOB, MAOA, CYP4B1 | ESR1 2616/4885MEN1 1030/4885KMT2A 522/4885 |
| US-20040229871-A1 | Phthalimido derivatives and a process for their preparation | MAOB, MAOA, CYP4B1 | ESR1 2616/4885MEN1 1030/4885KMT2A 522/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.