Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | RXRA | P19793 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | NPY1R | P25929 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPY2R | P49146 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GUSB | P08236 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6310295 | 1.00 | LMNA (0.54) | LMNAMEN1KMT2ARXRAKDM4E | |
| SCHEMBL6306831 | 0.93 | LMNA (0.45) | LMNAMEN1KMT2ARXRAKDM4E | |
| SCHEMBL6306834 | 0.93 | LMNA (0.45) | LMNAMEN1KMT2ARXRAKDM4E | |
| SCHEMBL6310555 | 0.90 | LMNA (0.42) | LMNAMEN1KMT2ARXRAKDM4E | |
| SCHEMBL6310557 | 0.90 | LMNA (0.42) | LMNAMEN1KMT2ARXRAKDM4E | |
| SCHEMBL6314044 | 0.89 | MAPT (0.44) | LMNAKDM4ETP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL6314046 | 0.89 | MAPT (0.44) | LMNAKDM4ETP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL6309679 | 0.84 | MEN1 (0.55) | LMNAMEN1KMT2ARXRAKDM4E | |
| SCHEMBL6309674 | 0.84 | MEN1 (0.55) | LMNAMEN1KMT2ARXRAKDM4E | |
| SCHEMBL6315968 | 0.83 | ALDH1A1 (0.54) | LMNAMEN1KMT2AKDM4ENPY1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6890930-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |
| EP-1216235-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023365-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |