Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | F11 | P03951 | 1/20 | 0.42 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | UBE2N | P61088 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPY1R | P25929 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPY2R | P49146 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6310557 | 1.00 | LMNA (0.42) | LMNAF11CYP1A1CYP1A2NFE2L2 | |
| SCHEMBL6306834 | 0.94 | LMNA (0.45) | LMNAF11CYP1A1CYP1A2NFE2L2 | |
| SCHEMBL6306831 | 0.94 | LMNA (0.45) | LMNAF11CYP1A1CYP1A2NFE2L2 | |
| SCHEMBL6314044 | 0.90 | MAPT (0.44) | LMNACYP1A1CYP1A2NFE2L2CYP1B1 | |
| SCHEMBL6314046 | 0.90 | MAPT (0.44) | LMNACYP1A1CYP1A2NFE2L2CYP1B1 | |
| SCHEMBL6310302 | 0.90 | LMNA (0.54) | LMNAALDH1A1MAPTMAPK1KDM4E | |
| SCHEMBL6310295 | 0.90 | LMNA (0.54) | LMNAALDH1A1MAPTMAPK1KDM4E | |
| SCHEMBL6313768 | 0.83 | ALDH1A1 (0.48) | LMNAALDH1A1MAPTHPGDKDM4E | |
| SCHEMBL6313760 | 0.83 | ALDH1A1 (0.48) | LMNAALDH1A1MAPTHPGDKDM4E | |
| SCHEMBL6309679 | 0.81 | MEN1 (0.55) | LMNAALDH1A1MAPTHPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6890930-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |
| EP-1216235-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023365-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |