Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | UBE2N | P61088 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6314046 | 1.00 | MAPT (0.44) | MAPTTP53LMNACYP1A1CYP1A2 | |
| SCHEMBL6306831 | 0.93 | LMNA (0.45) | MAPTTP53LMNACYP1A1CYP1A2 | |
| SCHEMBL6306834 | 0.93 | LMNA (0.45) | MAPTTP53LMNACYP1A1CYP1A2 | |
| SCHEMBL6310557 | 0.90 | LMNA (0.42) | MAPTLMNACYP1A1CYP1A2NFE2L2 | |
| SCHEMBL6310555 | 0.90 | LMNA (0.42) | MAPTLMNACYP1A1CYP1A2NFE2L2 | |
| SCHEMBL6310302 | 0.89 | LMNA (0.54) | MAPTTP53LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL6310295 | 0.89 | LMNA (0.54) | MAPTTP53LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL6314867 | 0.83 | ALDH1A1 (0.45) | MAPTTP53LMNACYP1A2KDM4E | |
| SCHEMBL6314863 | 0.83 | ALDH1A1 (0.45) | MAPTTP53LMNACYP1A2KDM4E | |
| SCHEMBL5878481 | 0.81 | MAPT (0.40) | MAPTTP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6890930-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |
| EP-1216235-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023365-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |