Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL5169634 | 0.89 | MAOB (0.38) | SMN1; SMN2KDM4EGAAMAPTMEN1 | |
| Maleic Acid SCHEMBL5167283 | 0.85 | GRM5 (0.39) | EGLN1KDM4EMAPK1TDP1GAA | |
| Fumaric Acid SCHEMBL5167292 | 0.85 | GRM5 (0.39) | EGLN1KDM4EMAPK1TDP1GAA | |
| Oxalic Acid SCHEMBL5167687 | 0.84 | ALDH1A1 (0.49) | EGLN1KDM4ETDP1MEN1KMT2A | |
| Fumaric Acid SCHEMBL5166201 | 0.83 | GRM5 (0.35) | EGLN1L3MBTL1MEN1KMT2AGRM5 | |
| Maleic Acid SCHEMBL5166190 | 0.83 | GRM5 (0.35) | EGLN1L3MBTL1MEN1KMT2AGRM5 | |
| Maleic Acid SCHEMBL6304442 | 0.83 | TDP1 (0.34) | FFAR1SMN1; SMN2MAPK1TDP1MAPT | |
| Fumaric Acid SCHEMBL6304447 | 0.83 | TDP1 (0.34) | FFAR1SMN1; SMN2MAPK1TDP1MAPT | |
| SCHEMBL5168898 | 0.82 | RAB9A (0.33) | MAPK1TDP1MAPTL3MBTL1MEN1 | |
| Oxalic Acid SCHEMBL6774216 | 0.82 | SMN1; SMN2 (0.45) | FFAR1SMN1; SMN2KDM4EMAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6964976-B2 | Amino alcohol derivatives | SANKYO COMPANY, LIMITED (JP) | 2005-11-15 | — | — | US | disclosed |
| US-20040132784-A1 | Amino alcohol derivatives | SANKYO COMPANY, LIMITED (JP) | 2004-07-08 | — | — | US | disclosed |
| US-20030236297-A1 | Amino alcohol derivatives | SANKYO COMPANY, LIMITED (JP) | 2003-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030236297-A1 | Amino alcohol derivatives | CD4, ADH1C, ADH1A | EGLN1 1053/4885ADRB2 202/4885ADRB1 67/4885 |
| US-20040132784-A1 | Amino alcohol derivatives | CD4, ADH1C, ADH1A | EGLN1 1053/4885ADRB2 202/4885ADRB1 67/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.