Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL58486 | 0.84 | TSHR (0.46) | TSHRLMNATDP1ALDH1A1GPR35 | |
| SCHEMBL2350187 | 0.74 | TSHR (0.38) | TSHRLMNATDP1ALDH1A1GPR35 | |
| SCHEMBL41321 | 0.74 | GPR35 (0.45) | TSHRLMNATDP1ALDH1A1GPR35 | |
| SCHEMBL261451 | 0.74 | TDP1 (0.45) | TSHRLMNATDP1ALDH1A1GPR35 | |
| SCHEMBL3317507 | 0.74 | ALDH1A1 (0.41) | TSHRLMNATDP1ALDH1A1GPR35 | |
| SCHEMBL28989354 | 0.70 | MAPT (0.42) | LMNATDP1ALDH1A1CYP1A2MAPT | |
| SCHEMBL28653988 | 0.70 | MAPT (0.39) | LMNATDP1ALDH1A1CYP1A2MAPT | |
| SCHEMBL9300521 | 0.70 | TDP1 (0.34) | TSHRLMNATDP1ALDH1A1ALOX15 | |
| SCHEMBL6047873 | 0.70 | PDE7A (0.33) | LMNAALDH1A1CYP3A4CYP2D6CTSB | |
| SCHEMBL11750501 | 0.70 | ERN1 (0.34) | ALDH1A1CYP1A2CYP3A4S100A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210395251-A1 | NAPHTHYRIDINONE COMPOUNDS AS JAK2 V617F INHIBITORS | INCYTE CORPORATION | 2021-12-23 | — | — | US | disclosed |
| US-20120208827-A1 | BENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC | 2012-08-16 | — | — | US | disclosed |
| CN-1829711-B | Novel heterocyclic compounds useful for the treatment of inflammatory and allergic disorders, process for their preparation and pharmaceutical compositions containing them | GLENMARK PHARMACEUTICALS INC U | 2010-06-16 | — | — | CN | disclosed |
| CN-101268075-A | Substituted tetrahydro-1H-pyrido[4,3-B]indoles as serotonin receptors agonists and antagonists | BRISTOL MYERS SQUIBB CO (US) | 2008-09-17 | — | — | CN | disclosed |
| CN-1217942-C | Pyrrolidine derivatives having phospholipase A inhibitory activity | SHIONOGI & CO (JP) | 2005-09-07 | — | — | CN | disclosed |
| US-6924301-B1 | Composition for treating or preventing arrhythmia | SHIONOGI & CO., LTD. (JP) | 2005-08-02 | — | — | US | disclosed |
| EP-1412364-A1 | PLATELET ADP RECEPTOR INHIBITORS | Portola Pharmaceuticals, Inc. (US) | 2004-04-28 | — | — | EP | disclosed |
| EP-0976748-B1 | PYRROLIDINE DERIVATIVES HAVING PHOSPHOLIPASE A2 INHIBITORY ACTIVITY | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| WO-2003011872-A1 | PLATELET ADP RECEPTOR INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2003-02-13 | — | — | WO | disclosed |
| EP-1240906-A1 | PREVENTIVES OR REMEDIES FOR ARRHYTHMIA | SHIONOGI & CO., LTD. (JP) | 2002-09-18 | — | — | EP | disclosed |
| US-6147100-A | ANTIINFLAMMATORY AGENTS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| CN-1251587-A | Pyrrolidine derivatives having phospholipase A inhibitory activity | SHIONOGI & CO (JP) | 2000-04-26 | — | — | CN | disclosed |
| EP-0976748-A1 | PYRROLIDINE DERIVATIVES HAVING PHOSPHOLIPASE A2 INHIBITORY ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2000-02-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120208827-A1 | BENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS | FASN, FADS1, FADS2 | TSHR 3642/4885LMNA 3101/4885TDP1 3460/4885 |
| US-20210395251-A1 | NAPHTHYRIDINONE COMPOUNDS AS JAK2 V617F INHIBITORS | JAK2, JAK1, JAK3 | TSHR 2306/4885LMNA 2529/4885TDP1 2069/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.