Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 7/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 7/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CDC42 | P60953 | 1/20 | 0.49 |
| ▸ | RAC1 | P63000 | 1/20 | 0.49 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8072598 | 0.81 | MTNR1B (0.42) | AKR1C3AKR1C2PTGS1LMNAAKR1C1 | |
| SCHEMBL28512510 | 0.81 | ABCB11 (0.53) | ABCB11AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL3949900 | 0.78 | ABCB11 (0.42) | ABCB11AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL6376525 | 0.78 | MTNR1A (0.42) | CYP1A2MAPTMTNR1AMTNR1B | |
| SCHEMBL29859207 | 0.76 | ADRA2A (0.45) | PTGS2PTGS1CYP1A2MTNR1AMTNR1B | |
| SCHEMBL28745848 | 0.76 | CPS1 (0.42) | CYP1A2MTNR1AMTNR1B | |
| SCHEMBL2292153 | 0.76 | ADRA2A (0.45) | PTGS2PTGS1CYP1A2MTNR1AMTNR1B | |
| SCHEMBL5359575 | 0.76 | NPC1 (0.45) | L3MBTL1 | |
| SCHEMBL3284398 | 0.76 | AKR1C3 (0.57) | ABCB11AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL23255697 | 0.74 | ABCB11 (0.66) | ABCB11AKR1C3AKR1C2PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272786-A1 | Naphthyl benzoxazoles and benzisoxazoles as estrogenic agents | WYETH (US) | 2005-12-08 | — | — | US | disclosed |
| US-6960607-B2 | Naphthyl benzoxazoles and benzisoxazoles as estrogenic agents | WYETH (US) | 2005-11-01 | — | — | US | disclosed |
| US-20030171412-A1 | Naphthyl benzoxazoles and benzisoxazoles as estrogenic agents | WYETH | 2003-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030171412-A1 | Naphthyl benzoxazoles and benzisoxazoles as estrogenic agents | ESR1, ESR2, ESRRA | ABCB11 300/4885AKR1C3 1063/4885AKR1C2 1240/4885 |
| US-20050272786-A1 | Naphthyl benzoxazoles and benzisoxazoles as estrogenic agents | ESR1, ESRRA, ESR2 | ABCB11 236/4885AKR1C3 534/4885AKR1C2 784/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.