Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 3/20 | 0.34 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 3/20 | 0.32 |
| ▸ | EP300 | Q09472 | 1/20 | 0.32 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8080080 | 0.77 | MAPT (0.36) | — | |
| SCHEMBL8620692 | 0.72 | CREBBP (0.37) | CREBBPBRPF1BRD4EP300 | |
| SCHEMBL17376745 | 0.60 | CREBBP (0.42) | CREBBPBRPF1BRD4EP300NOX1 | |
| SCHEMBL13349415 | 0.60 | PBRM1 (0.31) | — | |
| SCHEMBL19004692 | 0.58 | HSPA1A (0.38) | — | |
| SCHEMBL3319641 | 0.56 | CREBBP (0.39) | CREBBPBRPF1BRD4EP300 | |
| SCHEMBL12841651 | 0.56 | CREBBP (0.39) | CREBBPBRPF1BRD4EP300NOX1 | |
| SCHEMBL8279432 | 0.56 | CREBBP (0.50) | CREBBPBRPF1BRD4EP300 | |
| SCHEMBL5458130 | 0.56 | IDO1 (0.46) | CREBBPBRPF1BRD4EP300NOX1 | |
| SCHEMBL4265282 | 0.56 | CREBBP (0.39) | CREBBPBRPF1BRD4EP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6930185-B2 | Melanin-concentrating hormone antagonist | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2005-08-16 | — | — | US | disclosed |
| US-20040077628-A1 | Melanin-concentrating hormone antagonist | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-04-22 | — | — | US | disclosed |
| EP-1285651-A1 | MELANIN CONCENTRATING HORMONE ANTAGONISTS | Takeda Chemical Industries, Ltd. (JP) | 2003-02-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040077628-A1 | Melanin-concentrating hormone antagonist | MCHR1, MC1R, MCHR2 | CREBBP 2722/4885BRPF1 2596/4885BRD4 1951/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.