Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 8/20 | 0.50 |
| ▸ | HTR1B | P28222 | 7/20 | 0.50 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6346063 | 0.88 | HTR1D (0.40) | HTR1DHTR1BHTR1AHTR7 | |
| SCHEMBL6307093 | 0.85 | HTR1D (0.38) | HTR1DHTR1BHTR1AHTR7 | |
| SCHEMBL6307098 | 0.85 | HTR1D (0.38) | HTR1DHTR1BHTR1AHTR7 | |
| SCHEMBL6306827 | 0.82 | HTR1D (0.36) | HTR1DHTR1BHTR1AHTR7 | |
| SCHEMBL6308041 | 0.81 | HTR1A (0.41) | HTR1DHTR1BHTR1AHTR7 | |
| SCHEMBL8894150 | 0.80 | HTR1D (0.60) | HTR1DHTR1BHTR1A | |
| SCHEMBL6304652 | 0.79 | HTR1A (0.43) | HTR1DHTR1BHTR1A | |
| SCHEMBL6308276 | 0.78 | HTR1D (0.39) | HTR1DHTR1BHTR1AHTR7 | |
| SCHEMBL6305587 | 0.77 | HTR7 (0.45) | HTR1DHTR1BHTR1AHTR7 | |
| SCHEMBL6307417 | 0.70 | HTR7 (0.34) | HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050043387-A1 | Tricyclic indole compounds having an affinity against serotonin receptors | FUKUI YOSHIKAZU (JP) | 2005-02-24 | — | — | US | disclosed |
| US-6858640-B2 | Tricyclic indole compounds having affinity for serotonin receptor | SHIONOGI & CO., LTD. (JP) | 2005-02-22 | — | — | US | disclosed |
| US-20030236295-A1 | Tricylic indole compounds having affinity for serotonin receptor | SHIONOGI & CO., LTD. (JP) | 2003-12-25 | — | — | US | disclosed |
| EP-1325909-A1 | TRICYCLIC INDOLE COMPOUNDS HAVING AFFINITY FOR SEROTONIN RECEPTOR | SHIONOGI & CO., LTD. (JP) | 2003-07-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043387-A1 | Tricyclic indole compounds having an affinity against serotonin receptors | HTR4, TPH1, HRH4 | HTR1D 24/4885HTR1B 10/4885HTR1A 6/4885 |
| US-20030236295-A1 | Tricylic indole compounds having affinity for serotonin receptor | HTR4, HRH4, TPH1 | HTR1D 27/4885HTR1B 26/4885HTR1A 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.