Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.50 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 7/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.39 |
| ▸ | ITGAV | P06756 | 1/20 | 0.39 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.39 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5747316 | 1.00 | RIPK1 (0.50) | RIPK1PRMT5WDR77POLBHCRTR2 | |
| SCHEMBL6310462 | 1.00 | RIPK1 (0.50) | RIPK1PRMT5WDR77POLBHCRTR2 | |
| SCHEMBL5747318 | 1.00 | RIPK1 (0.50) | RIPK1PRMT5WDR77POLBHCRTR2 | |
| SCHEMBL6312120 | 0.83 | ITGB3 (0.44) | RIPK1PRMT5WDR77HCRTR2NPC1 | |
| SCHEMBL5968844 | 0.78 | RIPK1 (0.51) | RIPK1POLBSMN1; SMN2DPP4 | |
| SCHEMBL6310814 | 0.77 | RIPK1 (0.50) | RIPK1POLBTACR1EPHX2NPC1 | |
| SCHEMBL5747606 | 0.77 | RIPK1 (0.50) | RIPK1POLBTACR1EPHX2NPC1 | |
| SCHEMBL28087199 | 0.77 | RIPK1 (0.50) | RIPK1POLBEPHX2SMN1; SMN2DPP4 | |
| SCHEMBL5746649 | 0.77 | RIPK1 (0.50) | RIPK1POLBTACR1EPHX2NPC1 | |
| SCHEMBL5746647 | 0.77 | RIPK1 (0.50) | RIPK1POLBTACR1EPHX2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050043354-A1 | NK1 antagonist | PFIZER INC | 2005-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043354-A1 | NK1 antagonist | TACR2, TACR1, TAC3 | RIPK1 2280/4885PRMT5 2867/4885WDR77 2852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.