Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 2/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.37 |
| ▸ | VRK1 | Q99986 | 1/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.36 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.36 |
| ▸ | BCL6 | P41182 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6318862 | 0.83 | DHFR (0.56) | PIK3CATNFGRM4ADORA2AADORA1 | |
| SCHEMBL6318945 | 0.80 | TNF (0.44) | PIK3CATNFGRM4DHFRNPSR1 | |
| SCHEMBL6315288 | 0.79 | PDGFRB (0.49) | PIK3CATNFGRM4ADORA2AADORA1 | |
| SCHEMBL6313300 | 0.78 | ABCG2 (0.46) | PIK3CATNFGRM4ADORA2AADORA1 | |
| SCHEMBL6313731 | 0.78 | PIK3CA (0.41) | PIK3CATNFGRM4ADORA2AADORA1 | |
| SCHEMBL6312244 | 0.77 | CYP1A2 (0.52) | DYRK1APIK3CATNFADORA2AADORA1 | |
| SCHEMBL6312550 | 0.77 | CA12 (0.56) | PIK3CATNFGRM4 | |
| SCHEMBL4401602 | 0.77 | DYRK1A (0.44) | DYRK1APIK3CARIPK1IKBKBADORA1 | |
| SCHEMBL6320672 | 0.76 | MAPT (0.50) | PIK3CADHFRNPSR1 | |
| SCHEMBL6319736 | 0.76 | CDC7 (0.47) | PIK3CATNFGRM4DHFRTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6939874-B2 | Substituted pyrimidinyl derivatives and methods of use | AMGEN INC. (US) | 2005-09-06 | — | — | US | disclosed |