Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.46 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | BUB1 | O43683 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6318945 | 0.87 | TNF (0.44) | ALDH1A1GRM4TNFPIK3CANPSR1 | |
| SCHEMBL6318862 | 0.85 | DHFR (0.56) | ADORA2AADORA1GRM4TNFPIK3CA | |
| SCHEMBL6313731 | 0.84 | PIK3CA (0.41) | ADORA2AADORA1RAB9AGRM4TNF | |
| SCHEMBL6312550 | 0.83 | CA12 (0.56) | ALDH1A1RAB9AGRM4TNFPIK3CA | |
| SCHEMBL6320672 | 0.80 | MAPT (0.50) | RAB9APIK3CANPSR1SMN1; SMN2FAAH | |
| SCHEMBL6313300 | 0.80 | ABCG2 (0.46) | ADORA2AADORA1GRM4TNFPIK3CA | |
| SCHEMBL6312236 | 0.80 | MAP4K4 (0.45) | ADORA2AADORA1GRM4TNFPIK3CA | |
| SCHEMBL6312017 | 0.79 | CA2 (0.46) | ALDH1A1RAB9ATNFPIK3CAKDM4E | |
| SCHEMBL6313258 | 0.79 | DYRK1A (0.43) | ADORA2AADORA1GRM4TNFPIK3CA | |
| SCHEMBL6312244 | 0.79 | CYP1A2 (0.52) | ADORA2AADORA1ALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6939874-B2 | Substituted pyrimidinyl derivatives and methods of use | AMGEN INC. (US) | 2005-09-06 | — | — | US | disclosed |