Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 2/20 | 0.40 |
| ▸ | BCL6 | P41182 | 2/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | TEK | Q02763 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6320672 | 0.87 | MAPT (0.50) | PIK3CADHFRNPSR1RAB9AKMT2A | |
| SCHEMBL6318862 | 0.86 | DHFR (0.56) | PIK3CATNFGRM4ADORA2AADORA1 | |
| SCHEMBL6318945 | 0.85 | TNF (0.44) | PIK3CATNFGRM4BCL6DHFR | |
| SCHEMBL6315288 | 0.84 | PDGFRB (0.49) | PIK3CATNFGRM4ADORA2AADORA1 | |
| SCHEMBL6312550 | 0.81 | CA12 (0.56) | PIK3CATNFGRM4KDRRAB9A | |
| SCHEMBL6315312 | 0.80 | IGF1R (0.54) | ADORA2AADORA1IGF1RKDRTEK | |
| SCHEMBL6321509 | 0.79 | IGF1R (0.60) | ADORA2AADORA1IGF1RKDRTEK | |
| SCHEMBL6315310 | 0.78 | ADORA1 (0.45) | PIK3CATNFADORA2AADORA1IGF1R | |
| SCHEMBL6312244 | 0.78 | CYP1A2 (0.52) | PIK3CATNFADORA2AADORA1TEK | |
| SCHEMBL6313634 | 0.78 | ALPL (0.49) | PIK3CATNFADORA2AADORA1IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6939874-B2 | Substituted pyrimidinyl derivatives and methods of use | AMGEN INC. (US) | 2005-09-06 | — | — | US | disclosed |