Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.53 |
| ▸ | NOS1 | P29475 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.53 |
| ▸ | METAP2 | P50579 | 1/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | CLK1 | P49759 | 2/20 | 0.51 |
| ▸ | MAOB | P27338 | 5/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4171090 | 0.80 | MAPT (0.49) | MAPTKDM4ENOS1ALDH1A1ROCK2 | |
| SCHEMBL13608852 | 0.77 | MAPT (0.49) | MAPTKDM4ENOS1ALDH1A1ROCK2 | |
| SCHEMBL3514335 | 0.77 | MAPT (0.49) | MAPTKDM4ENOS1ALDH1A1ROCK2 | |
| SCHEMBL277776 | 0.74 | ROCK2 (0.59) | MAPTKDM4ENOS1ALDH1A1ROCK2 | |
| SCHEMBL8022440 | 0.74 | NOS1 (0.59) | MAPTKDM4ENOS1ALDH1A1ROCK2 | |
| Nitric Acid SCHEMBL6033263 | 0.72 | MAPT (0.52) | MAPTKDM4ENOS1ALDH1A1ROCK2 | |
| SCHEMBL28548770 | 0.72 | ROCK2 (0.49) | MAPTKDM4ENOS1ALDH1A1ROCK2 | |
| SCHEMBL9973869 | 0.71 | PIK3C3 (0.37) | MAPTKDM4EROCK2MEN1KMT2A | |
| SCHEMBL3997427 | 0.71 | NOS1 (0.55) | MAPTKDM4ENOS1ALDH1A1ROCK2 | |
| SCHEMBL3995547 | 0.69 | NOS1 (0.59) | MAPTKDM4ENOS1ALDH1A1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11034673-B2 | (S)-N-(3-(6-isopropoxypyridin-3-yl)-1H-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2H)-yl)-2-oxoethyl)-3-(methylthio)pyrrolidine-3-carboxamide compositions for pharmaceutical preparations | MERCK SHARP & DOHME CORP. (US) | 2021-06-15 | — | — | US | disclosed |
| US-20200299266-A1 | (S)-N-(3-(6-ISOPROPOXYPYRIDIN-3-YL)-1H-INDAZOL-5-YL)-1-(2-(4-(4-(1-METHYL-1H-1,2,4-TRIAZOL-3-YL)PHENYL)-3,6-DIHYDROPYRIDIN-1(2H)-YL)-2-OXOETHYL)-3-(METHYLTHIO)PYRROLIDINE-3-CARBOXAMIDE COMPOSITIONS FOR PHARMACEUTICAL PREPARATIONS | MERCK SHARP & DOHME CORP. (US) | 2020-09-24 | — | — | US | disclosed |
| EP-2573853-B1 | Electrolyte for lithium secondary battery and lithium secondary battery including the same | SAMSUNG ELECTRONICS CO LTD (KR) | 2020-09-09 | — | — | EP | disclosed |
| WO-2019144132-A1 | ESTROGEN RECEPTOR-MODULATING COMPOUNDS | RADIUS PHARMACEUTICALS, INC. (US) | 2019-07-25 | — | — | WO | disclosed |
| WO-2017121444-A1 | QUINOLIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2017-07-20 | — | — | WO | disclosed |
| US-7589199-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2009-09-15 | — | — | US | disclosed |
| US-7449576-B1 | potent antagonists of the CCR1 receptor; inflammation; (5-Chloro-2-piperazin-1-yl-phenyl)-phenyl-methanone | CHEMOCENTRYX, INC. (US) | 2008-11-11 | — | — | US | disclosed |
| US-7435830-B2 | Bicyclic and bridged nitrogen heterocycles | CHEMOCENTRYX, INC. (US) | 2008-10-14 | — | — | US | disclosed |
| CN-1262882-C | Anti-foaming agent compsotion for preparing silver halide photosensitive solution and method for making silver halide photographic material by using it | FUJI PHOTO FILM CO LTD (JP) | 2006-07-05 | — | — | CN | disclosed |
| US-6952294-B2 | Method of reading an image, method of forming a color image, device for forming a color image, silver halide color photosensitive material, and a device for processing a photosensitive material | FUJI PHOTO FILM CO., LTD. (JP) | 2005-10-04 | — | — | US | disclosed |
| US-4797349-A | USING A DEVELOPER CONTAINING A COLORLESS ANIONIC SURFACTANT HAVING SULFO, SULFATE, SULFONE OR SULFITE GROUPS; COLOR DENSITY | FUJI PHOTO FILM CO., LTD. (JP) | 1989-01-10 | — | — | US | disclosed |
| EP-0294769-A2 | Method for processing silver halide color photographic light-sensitive materials | FUJI PHOTO FILM CO., LTD. (JP) | 1988-12-14 | — | — | EP | disclosed |
| US-4783394-A | Color image forming process | FUJI PHOTO FILM CO., LTD. (JP) | 1988-11-08 | — | — | US | disclosed |
| EP-0289008-A2 | Method for processing silver halide color photographic light-sensitive materials | FUJI PHOTO FILM CO., LTD. (JP) | 1988-11-02 | — | — | EP | disclosed |
| EP-0289007-A2 | Method for processing silver halide color photographic light-sensitive material | FUJI PHOTO FILM CO., LTD. (JP) | 1988-11-02 | — | — | EP | disclosed |
| US-4774166-A | CONTAINING A NONCOLORING COMPOUND-AROMATIC ALCOHOL, ETHER, OR SULFONAMIDE | FUJI PHOTO FILM CO., LTD. (JP) | 1988-09-27 | — | — | US | disclosed |
| EP-0234428-A2 | Color image-forming process | FUJI PHOTO FILM CO., LTD. (JP) | 1987-09-02 | — | — | EP | disclosed |
| EP-0232770-A2 | Method of the formation of color images | FUJI PHOTO FILM CO., LTD. (JP) | 1987-08-19 | — | — | EP | disclosed |
| EP-0231870-A2 | Method for color image formation | FUJI PHOTO FILM CO., LTD. (JP) | 1987-08-12 | — | — | EP | disclosed |
| EP-0231832-A2 | Method of color image formation | FUJI PHOTO FILM CO., LTD. (JP) | 1987-08-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200299266-A1 | (S)-N-(3-(6-ISOPROPOXYPYRIDIN-3-YL)-1H-INDAZOL-5-YL)-1-(2-(4-(4-(1-METHYL-1H-1,2,4-TRIAZOL-3-YL)PHENYL)-3,6-DIHYDROPYRIDIN-1(2H)-YL)-2-OXOETHYL)-3-(METHYLTHIO)PYRROLIDINE-3-CARBOXAMIDE COMPOSITIONS FOR PHARMACEUTICAL PREPARATIONS | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HK1, HINT1 | MAPT 123/4885KDM4E 487/4885NOS1 3317/4885 |
| US-11034673-B2 | (S)-N-(3-(6-isopropoxypyridin-3-yl)-1H-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2H)-yl)-2-oxoethyl)-3-(methylthio)pyrrolidine-3-carboxamide compositions for pharmaceutical preparations | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HK1, HINT1 | MAPT 118/4885KDM4E 484/4885NOS1 3207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.