Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 5/20 | 0.59 |
| ▸ | NOS1 | P29475 | 4/20 | 0.59 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | METAP2 | P50579 | 1/20 | 0.59 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 1/20 | 0.55 |
| ▸ | CLK1 | P49759 | 2/20 | 0.53 |
| ▸ | GSK3B | P49841 | 2/20 | 0.53 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL277779 | 0.83 | NOS1 (0.59) | NOS1MAPTMETAP2CSNK2A1KDM4E | |
| SCHEMBL3997427 | 0.75 | NOS1 (0.55) | ROCK2NOS1ROCK1MAPTMETAP2 | |
| SCHEMBL907620 | 0.74 | NOS1 (0.59) | ROCK2NOS1ROCK1MAPTMETAP2 | |
| SCHEMBL5562 | 0.74 | NOS1 (1.00) | ROCK2NOS1ROCK1MAPTMETAP2 | |
| SCHEMBL3497213 | 0.74 | TRPA1 (0.59) | ROCK2NOS1ROCK1MAPTMETAP2 | |
| SCHEMBL264176 | 0.74 | NOS1 (1.00) | ROCK2NOS1ROCK1MAPTMETAP2 | |
| SCHEMBL3995547 | 0.74 | NOS1 (0.59) | ROCK2NOS1ROCK1MAPTMETAP2 | |
| SCHEMBL3540025 | 0.74 | NOS1 (1.00) | ROCK2NOS1ROCK1MAPTMETAP2 | |
| SCHEMBL117208 | 0.74 | ROCK2 (1.00) | ROCK2NOS1ROCK1MAPTMETAP2 | |
| SCHEMBL277777 | 0.74 | ROCK2 (0.59) | ROCK2NOS1ROCK1MAPTMETAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113439080-B | Vinylpyridine carboxamides as PD-L1 immunomodulators | 上海复星医药产业发展有限公司 | 2022-12-20 | — | — | CN | disclosed |
| US-20220144806-A1 | VINYLPYRIDINE CARBOXAMIDE COMPOUND AS PD-L1 IMMUNOMODULATOR | ShanghaiFosunPharmaceuticalIndustrialDevelopmentCo., (CN) | 2022-05-12 | — | — | US | disclosed |
| US-20220119368-A1 | FLUOROVINYLBENZAMIDE COMPOUND AS PD-L1 IMMUNOMODULATOR | ShanghaiFosunPharmaceuticalIndustrialDevelopmentCo.,Ltd (CN) | 2022-04-21 | — | — | US | disclosed |
| EP-3919478-A1 | VINYLPYRIDINE CARBOXAMIDE COMPOUND AS PD-L1 IMMUNOMODULATOR | Medshine Discovery Inc. (CN) | 2021-12-08 | — | — | EP | disclosed |
| EP-3919477-A1 | FLUOROVINYLBENZAMIDE COMPOUND AS PD-L1 IMMUNOMODULATOR | Medshine Discovery Inc. (CN) | 2021-12-08 | — | — | EP | disclosed |
| CN-113439080-A | Vinylpyridine carboxamides as PD-L1 immunomodulators | 南京明德新药研发有限公司 | 2021-09-24 | — | — | CN | disclosed |
| CN-112752749-B | Fluorovinylbenzamide compounds as PD-L1 immunomodulators | 南京明德新药研发有限公司 | 2021-07-16 | — | — | CN | disclosed |
| CN-107922349-B | Vinyl compounds as FGFR and VEGFR inhibitors | 哈尔滨珍宝制药有限公司 | 2021-05-07 | — | — | CN | disclosed |
| CN-112752749-A | Fluorovinylbenzamide compounds as PD-L1 immunomodulators | 南京明德新药研发有限公司 | 2021-05-04 | — | — | CN | disclosed |
| EP-3333157-B1 | VINYL COMPOUNDS AS FGFR AND VEGFR INHIBITORS | HARBIN ZHENBAO PHARMACEUTICAL CO LTD (CN) | 2020-12-23 | — | — | EP | disclosed |
| EP-1947101-A1 | HYDRAZIDE COMPOUND AND THROMBOPOIETIN RECEPTOR ACTIVATOR | Nissan Chemical Industries, Ltd. (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7351841-B2 | Heterocyclic compounds and thrombopoietin receptor activators | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2008-04-01 | — | — | US | disclosed |
| US-20080027068-A1 | HETEROCYCLIC COMPOUNDS AND THROMBOPOIETIN RECEPTOR ACTIVATORS | NISSAN CHEMICAL INDUSTRIES LIMITED (JP) | 2008-01-31 | — | — | US | disclosed |
| EP-1845090-A1 | AMIDE COMPOUND AND THROMBOPOIETIN RECEPTOR ACTIVATOR | Nissan Chemical Industries, Ltd. (JP) | 2007-10-17 | — | — | EP | disclosed |
| EP-1819692-A1 | 3-ETHYLIDENEHYDRAZINO SUBSTITUTED HETEROCYCLIC COMPOUNDS AS THROMBOPOIETIN RECEPTOR ACTIVATORS | Nissan Chemical Industries, Ltd. (JP) | 2007-08-22 | — | — | EP | disclosed |
| CN-1798739-A | 3-alkylidenehydrazino substituted heteroaryl compounds as thrombopoietin receptor activators | NISSAN CHEMICAL IND LTD (JP) | 2006-07-05 | — | — | CN | disclosed |
| WO-2006062240-A1 | 3-ETHYLIDENEHYDRAZINO SUBSTITUTED HETEROCYCLIC COMPOUNDS AS THROMBOPOIETIN RECEPTOR ACTIVATORS | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2006-06-15 | — | — | WO | disclosed |
| US-20060094694-A1 | Heterocyclic compounds and thrombopoietin receptor activators | NISSAN CHEMICAL INDUSTRIES LIMITED (JP) | 2006-05-04 | — | — | US | disclosed |
| EP-1636192-A1 | 3-ALKYLIDENEHYDRAZINO SUBSTITUTED HETEROARYL COMPOUNDS AS THROMBOPOIETIN RECEPTOR ACTIVATORS | Nissan Chemical Industries, Ltd. (JP) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004108683-A1 | 3-ALKYLIDENEHYDRAZINO SUBSTITUTED HETEROARYL COMPOUNDS AS THROMBOPOIETIN RECEPTOR ACTIVATORS | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2004-12-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220144806-A1 | VINYLPYRIDINE CARBOXAMIDE COMPOUND AS PD-L1 IMMUNOMODULATOR | PDCD1, CD274, PDCD1LG2 | ROCK2 3190/4885NOS1 3600/4885ROCK1 3790/4885 |
| US-20060094694-A1 | Heterocyclic compounds and thrombopoietin receptor activators | NR2C2, ROR1, NR0B2 | ROCK2 3325/4885NOS1 1363/4885ROCK1 3396/4885 |
| US-20220119368-A1 | FLUOROVINYLBENZAMIDE COMPOUND AS PD-L1 IMMUNOMODULATOR | CD274, PDCD1LG2, PDCD1 | ROCK2 2949/4885NOS1 4457/4885ROCK1 3743/4885 |
| US-20080027068-A1 | HETEROCYCLIC COMPOUNDS AND THROMBOPOIETIN RECEPTOR ACTIVATORS | NR2C2, ROR1, NR0B2 | ROCK2 3331/4885NOS1 1328/4885ROCK1 3435/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.