Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 7/20 | 0.41 |
| ▸ | RXRB | P28702 | 6/20 | 0.41 |
| ▸ | RXRG | P48443 | 6/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | RARA | P10276 | 3/20 | 0.35 |
| ▸ | RARB | P10826 | 3/20 | 0.35 |
| ▸ | RARG | P13631 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.30 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5180347 | 0.82 | RXRA (0.59) | RXRARXRBRXRGPPARGNR1H3 | |
| SCHEMBL5178703 | 0.69 | RXRA (0.65) | RXRARXRBRXRGPPARGNR1H3 | |
| SCHEMBL5179745 | 0.69 | RXRA (0.61) | RXRARXRBRXRGPPARGNR1H3 | |
| SCHEMBL5179721 | 0.69 | RXRA (0.58) | RXRARXRBRXRGPPARGNR1H3 | |
| SCHEMBL10844326 | 0.69 | RARB (0.48) | RXRARXRBRXRGRARARARB | |
| SCHEMBL10844308 | 0.69 | RARB (0.48) | RXRARXRBRXRGRARARARB | |
| SCHEMBL5179533 | 0.67 | RXRA (0.72) | RXRARXRBRXRGPPARGNR1H3 | |
| SCHEMBL11530672 | 0.66 | ALDH1A1 (0.56) | CYP3A4CYP2C9CYP2C19ALDH1A1NPSR1 | |
| SCHEMBL501775 | 0.65 | RXRA (0.52) | RXRARXRBRXRGPPARGNR1H3 | |
| SCHEMBL5178994 | 0.64 | CYP2C9 (0.40) | KMT2AP2RY12CYP2C9CYP2C19HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6869959-B1 | Heterocyclic carboxylic acid derivatives | INSTITUTE OF MEDICINAL MOLECULAR DESIGN INC. (JP) | 2005-03-22 | — | — | US | disclosed |