Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 4/20 | 0.48 |
| ▸ | MMP9 | P14780 | 4/20 | 0.48 |
| ▸ | MMP12 | P39900 | 4/20 | 0.48 |
| ▸ | MMP14 | P50281 | 4/20 | 0.48 |
| ▸ | MMP1 | P03956 | 3/20 | 0.48 |
| ▸ | MMP3 | P08254 | 3/20 | 0.48 |
| ▸ | MMP8 | P22894 | 3/20 | 0.48 |
| ▸ | MMP13 | P45452 | 3/20 | 0.48 |
| ▸ | MMP16 | P51512 | 3/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 7/20 | 0.44 |
| ▸ | RXRA | P19793 | 2/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6307769 | 0.90 | HDAC1 (0.47) | MMP2MMP9MMP12MMP14MMP1 | |
| SCHEMBL6309782 | 0.87 | NR4A2 (0.49) | SCN9AF10RXRANR4A2F2 | |
| SCHEMBL6308687 | 0.87 | NR4A2 (0.44) | RXRANR4A2RXRBNR4A1NR4A3 | |
| SCHEMBL6310938 | 0.87 | NR4A2 (0.49) | F10RXRANR4A2RXRBNR4A1 | |
| SCHEMBL6315580 | 0.85 | PTGS2 (0.45) | SCN9AF10RXRANR4A2F2 | |
| SCHEMBL6315005 | 0.85 | PTGS2 (0.45) | SCN9AF10RXRA | |
| SCHEMBL8553402 | 0.85 | SCN9A (0.44) | SCN9AF10RXRANR4A2F2 | |
| SCHEMBL6314953 | 0.84 | CA9 (0.49) | MMP2MMP9MMP12MMP14MMP1 | |
| SCHEMBL6316519 | 0.83 | F10 (0.43) | SCN9AF10RXRANR4A2F2 | |
| SCHEMBL8561179 | 0.83 | NR4A2 (0.51) | RXRANR4A2RXRBNR4A1NR4A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6875785-B2 | Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors | PHARMACIA CORPORATION (US) | 2005-04-05 | — | — | US | claimed |