Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.42 |
| ▸ | RXRA | P19793 | 3/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 2/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 4/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.36 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6308151 | 0.91 | PTGS2 (0.48) | PTGS2PTGS1NR4A2RXRAEPHX2 | |
| SCHEMBL6315005 | 0.90 | PTGS2 (0.45) | PTGS2PTGS1RXRASCN9AF10 | |
| SCHEMBL8604402 | 0.89 | PTGS2 (0.43) | PTGS2PTGS1NR4A2RXRASCN9A | |
| SCHEMBL6309069 | 0.89 | NR4A2 (0.49) | PTGS2PTGS1NR4A2RXRAEPHX2 | |
| SCHEMBL8561125 | 0.86 | PTGS2 (0.47) | PTGS2PTGS1NR4A2RXRASCN9A | |
| SCHEMBL6309710 | 0.86 | NR4A2 (0.44) | PTGS2PTGS1NR4A2RXRAEPHX2 | |
| SCHEMBL6315576 | 0.85 | PTGS2 (0.50) | PTGS2PTGS1RXRAEPHX2RXRB | |
| SCHEMBL6314962 | 0.85 | MMP2 (0.48) | NR4A2RXRASCN9ARXRBF10 | |
| SCHEMBL6307441 | 0.84 | PTGS2 (0.44) | PTGS2PTGS1NR4A2RXRAEPHX2 | |
| SCHEMBL6310938 | 0.84 | NR4A2 (0.49) | NR4A2RXRARXRBRXRGF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6875785-B2 | Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors | PHARMACIA CORPORATION (US) | 2005-04-05 | — | — | US | claimed |