Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.45 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 4/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6315580 | 0.90 | PTGS2 (0.45) | PTGS2PTGS1RXRAF10SCN9A | |
| SCHEMBL8549844 | 0.88 | PTGS2 (0.52) | PTGS2PTGS1RXRAF10ALOX5AP | |
| SCHEMBL6315419 | 0.88 | PTGS2 (0.44) | PTGS2PTGS1RXRAF10ALOX5AP | |
| SCHEMBL8561414 | 0.86 | PTGS2 (0.47) | PTGS2PTGS1RXRASCN9AALOX5AP | |
| SCHEMBL6314997 | 0.85 | PTGS2 (0.52) | PTGS2PTGS1MEP1BCDK2 | |
| SCHEMBL6314962 | 0.85 | MMP2 (0.48) | RXRAF10SCN9A | |
| SCHEMBL6309710 | 0.85 | NR4A2 (0.44) | PTGS2PTGS1RXRAF10ALOX5AP | |
| SCHEMBL6315591 | 0.84 | PTGS2 (0.44) | PTGS2PTGS1RXRAF10ALOX5AP | |
| SCHEMBL6308687 | 0.84 | NR4A2 (0.44) | PTGS2PTGS1RXRACA9 | |
| SCHEMBL6310277 | 0.83 | RXRA (0.47) | PTGS2PTGS1RXRAF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6875785-B2 | Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors | PHARMACIA CORPORATION (US) | 2005-04-05 | — | — | US | claimed |