Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 12/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 12/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 12/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 11/20 | 0.51 |
| ▸ | TSHR | P16473 | 9/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6308808 | 0.80 | MAPT (0.49) | CYP1A2CYP3A4CYP2C19TSHRALDH1A1 | |
| SCHEMBL13887881 | 0.76 | SLC6A4 (0.68) | CYP2D6SLC6A4HTR2AKCNH2APLNR | |
| SCHEMBL5436698 | 0.76 | HIF1A (0.56) | HIF1AMEN1KMT2ASLC6A4HTR2A | |
| SCHEMBL4510419 | 0.70 | ALDH1A1 (0.53) | CYP1A2ALDH1A1SLC6A4HTR2AKCNH2 | |
| SCHEMBL8340513 | 0.70 | SLC6A4 (0.47) | ALDH1A1HSD17B10TDP1SLC6A4HTR2A | |
| SCHEMBL9096862 | 0.70 | SLC6A4 (0.46) | ALDH1A1TDP1MEN1KMT2ASLC6A4 | |
| SCHEMBL319266 | 0.70 | APLNR (0.63) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR | |
| SCHEMBL9096859 | 0.69 | CYP1A2 (0.52) | CYP1A2CYP2C19CYP2D6MEN1KMT2A | |
| SCHEMBL5753110 | 0.69 | ALDH1A1 (0.54) | ALDH1A1HSD17B10TDP1MEN1KMT2A | |
| SCHEMBL5975064 | 0.69 | IDO1 (0.55) | ALDH1A1MEN1KMT2ASLC6A4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6919339-B2 | ABCA-1 elevating compounds | CV THEAPEUTICS, INC. (US) | 2005-07-19 | — | — | US | disclosed |
| EP-1341773-A2 | SUBSTITUTED 1,3,5-TRIAZINES AND PYRIMIDINES AS ABCA-1 ELEVATING COMPOUNDS AGAINST CORONARY ARTERY DISEASE OR ATHEROSCLEROSIS | CV THERAPEUTICS, INC. (US) | 2003-09-10 | — | — | EP | disclosed |
| US-20020128266-A1 | ABCA-1 elevating compounds | CV THERAPEUTICS, INC. | 2002-09-12 | — | — | US | disclosed |
| WO-2002046172-A2 | SUBSTITUTED 1, 3, 5-TRIAZINES AND PYRIMIDINES AS ABCA-1 ELEVATING COMPOUNDS AGAINST CORONARY ARTERY DISEASE OR ATHEROSCLEROSIS | CV THERAPEUTICS, INC. (US) | 2002-06-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020128266-A1 | ABCA-1 elevating compounds | ABCD3, ABCE1, ABCB4 | CYP1A2 947/4885CYP3A4 1597/4885CYP2C19 2695/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.