Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | NFE2L2 | Q16236 | 6/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.53 |
| ▸ | TP53 | P04637 | 4/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SPR | P35270 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4452081 | 0.85 | SLC9A1 (0.57) | SMN1; SMN2TP53THRBMAPTPOLB | |
| SCHEMBL6314631 | 0.84 | NFE2L2 (0.64) | SMN1; SMN2NFE2L2KEAP1MAPTPOLB | |
| Hydrochloric Acid SCHEMBL7662228 | 0.84 | SLC9A1 (0.56) | SMN1; SMN2TP53THRBMAPTPOLB | |
| SCHEMBL6429715 | 0.84 | SMN1; SMN2 (0.47) | SMN1; SMN2TP53THRBMAPTPOLB | |
| SCHEMBL4452076 | 0.84 | TP53 (0.47) | SMN1; SMN2TP53THRBMAPTPOLB | |
| Hydrochloric Acid SCHEMBL6311494 | 0.83 | TP53 (0.46) | SMN1; SMN2TP53THRBMAPTPOLB | |
| SCHEMBL27527752 | 0.80 | HCAR1 (0.38) | SMN1; SMN2TP53THRBMAPTPOLB | |
| SCHEMBL6482935 | 0.77 | TP53 (0.43) | TP53THRBMAPTPOLBSHMT2 | |
| SCHEMBL6393490 | 0.77 | NFE2L2 (0.56) | SMN1; SMN2NFE2L2KEAP1MAPTPOLB | |
| SCHEMBL6320171 | 0.75 | NFE2L2 (0.68) | SMN1; SMN2NFE2L2KEAP1TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6974813-B2 | N-[(substituted five-membered di-or triaza diunsaturated ring) carbonyl] guanidine derivatives for the treatment of ischemia | WARNER-LAMBERT COMPANY (US) | 2005-12-13 | — | — | US | disclosed |
| EP-1454902-A1 | N- (substituted five-membered di-or triaza diunsaturated ring)carbonyl guanidine derivateives for the treatment of ischemia | Pfizer Products Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| US-20030149043-A1 | N-[(substituted five-membered di-or triaza diunsaturated ring)carbonyl] guanidine derivatives for the treatment of ischemia | PFIZER INC. | 2003-08-07 | — | — | US | disclosed |
| US-6492401-B1 | SODIUM HYDROGEN EXCHANGER TYPE 1 INHIBITORS; REDUCING PERIOPERATIVE MYOCARDIAL TISSUE DAMAGE | PFIZER, INC. | 2002-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030149043-A1 | N-[(substituted five-membered di-or triaza diunsaturated ring)carbonyl] guanidine derivatives for the treatment of ischemia | NHERF1, SLC28A1, TNNI3 | SMN1; SMN2 3122/4885NFE2L2 450/4885KEAP1 313/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.