Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6315679 | 0.79 | MAPT (0.37) | NPSR1MAPTMAPK1ADRA2AADRA2C | |
| SCHEMBL8712749 | 0.73 | NPSR1 (0.39) | NPSR1MAPTALDH1A1KDM4EHPGD | |
| SCHEMBL6316378 | 0.71 | ALDH1A1 (0.47) | NPSR1MAPTMAPK1ALDH1A1KDM4E | |
| SCHEMBL8714296 | 0.69 | KDM4E (0.35) | NPSR1MAPTALDH1A1KDM4EHPGD | |
| SCHEMBL6767205 | 0.69 | ELANE (0.41) | MAPTPTGDR2ALDH1A1KDM4EHPGD | |
| SCHEMBL8716048 | 0.68 | HPGD (0.48) | ALDH1A1HPGDMEN1KMT2ALMNA | |
| SCHEMBL6316455 | 0.68 | HIF1A (0.38) | NPSR1MAPTMAPK1ALDH1A1HPGD | |
| SCHEMBL8713940 | 0.67 | RAB9A (0.40) | NPSR1MAPTALDH1A1KDM4EHPGD | |
| SCHEMBL20711472 | 0.63 | ALDH1A1 (0.40) | NPSR1MAPTMAPK1ALDH1A1KDM4E | |
| SCHEMBL18562142 | 0.63 | PTGDR2 (0.41) | NPSR1MAPTMAPK1PTGDR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6872718-B1 | Tricyclic dihydrobenzofuran derivatives, process for the preparation thereof and agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2005-03-29 | — | — | US | disclosed |
| EP-1211253-B1 | TRICYCLIC DIHYDROBENZOFURAN DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-10-13 | — | — | EP | disclosed |
| EP-1211253-A1 | TRICYCLIC DIHYDROBENZOFURAN DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS | Takeda Chemical Industries, Ltd. (JP) | 2002-06-05 | — | — | EP | disclosed |