Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6315669 | 0.79 | NPSR1 (0.39) | MAPTMAPK1NPSR1ADRA2AADRA2C | |
| SCHEMBL6316378 | 0.75 | ALDH1A1 (0.47) | MAPTMAPK1NPSR1 | |
| SCHEMBL8712754 | 0.70 | POLB (0.38) | — | |
| SCHEMBL8713943 | 0.65 | NPC1 (0.41) | MAPTMAPK1NPSR1 | |
| SCHEMBL7524729 | 0.64 | KDM5A (0.34) | MAPTMAPK1NPSR1 | |
| SCHEMBL8716052 | 0.64 | HPGD (0.35) | — | |
| SCHEMBL23009244 | 0.64 | ADRA2A (0.51) | MAPTADRA2AADRA2CADRA1DADRA1A | |
| SCHEMBL8714301 | 0.62 | — | — | |
| SCHEMBL3251629 | 0.62 | GAA (0.45) | MAPTMAPK1NPSR1 | |
| SCHEMBL12288085 | 0.62 | ALDH1A1 (0.50) | MAPTMAPK1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6872718-B1 | Tricyclic dihydrobenzofuran derivatives, process for the preparation thereof and agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2005-03-29 | — | — | US | disclosed |
| EP-1211253-B1 | TRICYCLIC DIHYDROBENZOFURAN DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-10-13 | — | — | EP | disclosed |
| EP-1211253-A1 | TRICYCLIC DIHYDROBENZOFURAN DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS | Takeda Chemical Industries, Ltd. (JP) | 2002-06-05 | — | — | EP | disclosed |