Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ATP2A2 | P16615 | 1/20 | 0.47 |
| ▸ | ATP2A3 | Q93084 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12288085 | 0.82 | ALDH1A1 (0.50) | ALDH1A1ALOX15SMN1; SMN2TP53CYP3A4 | |
| SCHEMBL3251629 | 0.80 | GAA (0.45) | ALDH1A1ALOX15SMN1; SMN2TP53CYP3A4 | |
| SCHEMBL2741246 | 0.78 | ALOX15 (0.54) | ALDH1A1ALOX15SMN1; SMN2TP53CYP3A4 | |
| SCHEMBL21568087 | 0.77 | ALOX15 (0.49) | ALDH1A1ALOX15SMN1; SMN2TP53CYP3A4 | |
| SCHEMBL6315679 | 0.75 | MAPT (0.37) | MAPK1MAPTNPSR1 | |
| SCHEMBL6296216 | 0.73 | ALDH1A1 (0.52) | ALDH1A1ALOX15SMN1; SMN2TP53CYP3A4 | |
| SCHEMBL29872633 | 0.72 | ALOX15 (0.70) | ALDH1A1ALOX15SMN1; SMN2TP53CYP3A4 | |
| SCHEMBL395984 | 0.72 | ALOX15 (0.70) | ALDH1A1ALOX15SMN1; SMN2TP53CYP3A4 | |
| SCHEMBL6315669 | 0.71 | NPSR1 (0.39) | ALDH1A1SMN1; SMN2TP53MAPK1TSHR | |
| SCHEMBL20147097 | 0.71 | KDM5A (0.40) | ALDH1A1ALOX15SMN1; SMN2TP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6872718-B1 | Tricyclic dihydrobenzofuran derivatives, process for the preparation thereof and agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2005-03-29 | — | — | US | disclosed |
| EP-1211253-B1 | TRICYCLIC DIHYDROBENZOFURAN DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-10-13 | — | — | EP | disclosed |
| EP-1456172-A1 | PYRROLIDINE-2-ONES AS FACTOR XA INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-09-15 | — | — | EP | disclosed |
| WO-2003053925-A1 | PYRROLIDINE-2-ONES AS FACTOR XA INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-07-03 | — | — | WO | disclosed |