Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5872276 | 0.77 | SMN1; SMN2 (0.45) | KDM4ECYP1A2SMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL30593189 | 0.68 | SMN1; SMN2 (0.75) | SMN1; SMN2ALDH1A1MAPK1POLBL3MBTL1 | |
| SCHEMBL3227278 | 0.68 | SMN1; SMN2 (0.75) | SMN1; SMN2ALDH1A1MAPK1POLBL3MBTL1 | |
| SCHEMBL2630833 | 0.67 | ALDH1A1 (0.53) | KDM4ESMN1; SMN2ALDH1A1MAPK1TSHR | |
| SCHEMBL19212155 | 0.67 | POLB (0.76) | KDM4ECYP1A2SMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL11560282 | 0.65 | PCTP (0.54) | SMN1; SMN2ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL6031540 | 0.65 | SMN1; SMN2 (0.58) | SMN1; SMN2ALDH1A1MAPK1POLBL3MBTL1 | |
| SCHEMBL7706726 | 0.65 | SMN1; SMN2 (0.58) | KDM4ESMN1; SMN2ALDH1A1MAPK1GAA | |
| SCHEMBL31171378 | 0.64 | HTT (0.52) | KDM4ECYP1A2SMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL27803856 | 0.63 | SMN1; SMN2 (0.59) | SMN1; SMN2ALDH1A1MAPK1POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6900205-B2 | 1,8-Naphthyridine derivatives and their use to treat diabetes and related disorders | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-05-31 | — | — | US | disclosed |