Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.68 |
| ▸ | LMNA | P02545 | 3/20 | 0.68 |
| ▸ | MAOA | P21397 | 2/20 | 0.67 |
| ▸ | MAOB | P27338 | 2/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6325847 | 0.91 | MAPT (0.64) | MAPTLMNAL3MBTL1KDM4ERAB9A | |
| SCHEMBL6202777 | 0.87 | MAPT (0.64) | MAPTLMNAMAOBL3MBTL1KDM4E | |
| SCHEMBL6318934 | 0.87 | MAPT (0.78) | MAPTLMNAL3MBTL1KDM4ERAB9A | |
| SCHEMBL6321338 | 0.87 | MAPT (0.64) | MAPTLMNAL3MBTL1KDM4ERAB9A | |
| SCHEMBL6328277 | 0.87 | MAPT (0.64) | MAPTLMNAL3MBTL1KDM4ERAB9A | |
| SCHEMBL31357494 | 0.85 | MAPT (0.70) | MAPTLMNAL3MBTL1GAARAB9A | |
| SCHEMBL9787036 | 0.85 | MAPT (0.85) | MAPTLMNAMAOBL3MBTL1GAA | |
| SCHEMBL3868073 | 0.85 | MAPT (0.63) | MAPTLMNAL3MBTL1KDM4ERAB9A | |
| SCHEMBL18477949 | 0.84 | MAOB (0.73) | MAPTLMNAMAOAMAOBL3MBTL1 | |
| SCHEMBL3866097 | 0.84 | MAPT (0.57) | MAPTLMNAMAOAMAOBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| CN-1681763-A | Chemical compounds | ASTRAZENECA AB (SE) | 2005-10-12 | — | — | CN | disclosed |