SCHEMBL6320544

SCHEMBL6320544

[c]1cccc(-c2cncnc2)c1CNCC1CC1

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 2/20 0.35
MEN1 O00255 1/20 0.35
TP53 P04637 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
RECQL P46063 1/20 0.35
KMT2A Q03164 1/20 0.35
ROCK2 O75116 8/20 0.34
ROCK1 Q13464 8/20 0.34
CDC42BPB Q9Y5S2 8/20 0.34
IDO1 P14902 1/20 0.34
CDC42BPA Q5VT25 1/20 0.33
KCNH2 Q12809 1/20 0.33
GRIN2B Q13224 1/20 0.33
MAP4K4 O95819 2/20 0.33
KDM4C Q9H3R0 1/20 0.32
PIM1 P11309 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6325686 0.88 PIM1 (0.41) CYP2D6CYP2C9CYP2C19IDO1KDM4C
SCHEMBL6640607 0.83 MEN1 (0.42) CYP2D6MEN1TP53CYP3A4CYP2C9
SCHEMBL6331308 0.79 KDM4E (0.42) CYP2D6ROCK2ROCK1CDC42BPBCDC42BPA
SCHEMBL6324148 0.79 KDM4E (0.39) CYP2D6ROCK2ROCK1CDC42BPBCDC42BPA
SCHEMBL6322319 0.78 MEN1 (0.37) CYP2D6MEN1TP53CYP3A4CYP2C9
SCHEMBL6321221 0.75 GPR39 (0.42) CYP2D6MEN1TP53CYP3A4CYP2C9
SCHEMBL6643602 0.70 KMT2A (0.41) CYP2D6MEN1TP53CYP3A4CYP2C9
SCHEMBL6329476 0.69 ALDH1A1 (0.49) CYP2D6IDO1KCNH2GRIN2BPIM1
SCHEMBL6322030 0.69 ALDH1A1 (0.52) CYP2D6IDO1KCNH2GRIN2BPIM1
SCHEMBL6339684 0.69 CYP1A2 (0.37) CYP2D6CYP3A4CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6951872-B2 Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) 2005-10-04 US disclosed
US-6858616-B2 Nitrogen containing heterobicycles as factor Xa inhibitors BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) 2005-02-22 US disclosed
EP-1140871-A4 THROMBIN OR FACTOR XA INHIBITORS BRISTOL MYERS SQUIBB PHARMA CO (US) 2004-05-06 EP disclosed
US-6710058-B2 USE AS ANTICOAGULANT AGENTS FOR THERAPY AND PROPHYLAXIS OFTHROMBOEMBOLIC DISORDERS BRISTOL-MYERS SQUIBB PHARMA COMPANY 2004-03-23 US disclosed
US-6500855-B1 NITROGEN CONTAINING AROMATIC HETEROCYCLES WITH ORTHO-SUBSTITUTED P1 GROUPS; ANTICOAGULANTS BRISTOL-MYERS SQUIBB PHARMA COMPANY 2002-12-31 US disclosed
US-6413980-B1 INHIBITORS OF TRYPSIN-LIKE SERINE PROTEASE ENZYMES; ANTICOAGULANTS; THROMBOEMBOLIC DISORDERS BRISTOL-MYERS SQUIBB PHARMA COMPANY 2002-07-02 US disclosed
US-6369227-B1 BLOOD COAGULATION BRISTOL-MYERS SQUIBB PHARMA COMPANY 2002-04-09 US disclosed
EP-1140871-A1 THROMBIN OR FACTOR XA INHIBITORS Du Pont Pharmaceuticals Company (US) 2001-10-10 EP disclosed
EP-1140941-A1 NITROGEN CONTAINING HETEROBICYCLES AS FACTOR XA INHIBITORS Du Pont Pharmaceuticals Company (US) 2001-10-10 EP disclosed
WO-2000039131-A1 NITROGEN CONTAINING HETEROBICYCLES AS FACTOR XA INHIBITORS DU PONT PHARMACEUTICALS COMPANY (US) 2000-07-06 WO disclosed
WO-2000039108-A1 THROMBIN OR FACTOR XA INHIBITORS DU PONT PHARMACEUTICALS COMPANY (US) 2000-07-06 WO disclosed