Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.54 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.54 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.54 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.54 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.54 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.54 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 2/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 10/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6320952 | 1.00 | ALDH1A1 (0.57) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL6320944 | 1.00 | ALDH1A1 (0.57) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL8326734 | 0.91 | ALDH1A1 (0.69) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL1120610 | 0.90 | ACHE (0.65) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL1120608 | 0.90 | ACHE (0.65) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL1120612 | 0.90 | ACHE (0.65) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL4371767 | 0.90 | ALDH1A1 (0.56) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL4371662 | 0.90 | ALDH1A1 (0.56) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL5406154 | 0.89 | ALDH1A1 (0.55) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL5406159 | 0.89 | ALDH1A1 (0.55) | ALDH1A1LMNATP53MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050124574-A1 | Purine derivatives | PFIZER INC. | 2005-06-09 | — | — | US | disclosed |
| US-6900309-B1 | Purine derivatives | PFIZER INC (US) | 2005-05-31 | — | — | US | disclosed |
| EP-1185542-A2 | PURINE DERIVATIVES | Pfizer Limited (GB) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000077018-A2 | PURINE DERIVATIVES | PFIZER LIMITED (GB) | 2000-12-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124574-A1 | Purine derivatives | ADORA2A, ADORA3, ADORA1 | ALDH1A1 544/4885LMNA 2187/4885TP53 3178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.