Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB known ✓ | P27338 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | IDO1 | P14902 | 3/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | CASP1 | P29466 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6321756 | 0.91 | HSD17B10 (0.46) | HSD17B10ALDH1A1CYP3A4TSHRTDP1 | |
| Hydrochloric Acid SCHEMBL4679683 | 0.89 | HSD17B10 (0.45) | HSD17B10ALDH1A1CYP3A4TSHRTDP1 | |
| Sulfuric Acid SCHEMBL28375821 | 0.76 | PTGS2 (0.46) | ALDH1A1CYP3A4IDO1GAACA2 | |
| SCHEMBL7568541 | 0.74 | HSD17B10 (0.48) | HSD17B10ALDH1A1CYP3A4TSHRTDP1 | |
| Sulfuric Acid SCHEMBL28200761 | 0.73 | SOS1 (0.46) | HSD17B10ALDH1A1TSHRHPGDTHRB | |
| SCHEMBL1702377 | 0.72 | HSD17B10 (0.46) | HSD17B10ALDH1A1CYP3A4TSHRTDP1 | |
| Hydrochloric Acid SCHEMBL8073459 | 0.72 | HSD17B10 (0.46) | HSD17B10ALDH1A1CYP3A4TSHRTDP1 | |
| SCHEMBL15934314 | 0.67 | HSD17B10 (0.50) | HSD17B10ALDH1A1CYP3A4TSHRTDP1 | |
| SCHEMBL10422850 | 0.67 | ALDH1A1 (0.55) | HSD17B10ALDH1A1CYP3A4TSHRTDP1 | |
| SCHEMBL17603210 | 0.67 | EPHX1 (0.52) | HSD17B10ALDH1A1CYP3A4TSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6852890-B1 | Process for the preparation of phenylhydrazines | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2005-02-08 | — | — | US | disclosed |
| EP-1175393-B1 | PROCESS FOR THE PREPARATION OF PHENYLHYDRAZINES | SUMITOMO CHEMICAL CO (JP) | 2004-06-09 | — | — | EP | disclosed |