Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | EDNRA | P25101 | 4/20 | 0.39 |
| ▸ | EDNRB | P24530 | 3/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGAV | P06756 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GHSR | Q92847 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6320795 | 0.91 | EDNRA (0.39) | EDNRAEDNRBITGB3ITGAVALDH1A1 | |
| SCHEMBL8710102 | 0.91 | EPHX2 (0.42) | TDP1ITGB3ITGAVL3MBTL1MEN1 | |
| SCHEMBL8711325 | 0.90 | EGFR (0.40) | ITGB3ITGAVMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8710009 | 0.90 | GAA (0.41) | TDP1EDNRBITGB3ITGAVALDH1A1 | |
| SCHEMBL8711199 | 0.90 | MRGPRX4 (0.41) | EDNRAEDNRBITGB3ITGAVMEN1 | |
| SCHEMBL8712259 | 0.88 | BMP1 (0.43) | MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL8712035 | 0.87 | EDNRA (0.39) | TDP1EDNRAITGB3ITGAVL3MBTL1 | |
| SCHEMBL8709961 | 0.86 | ITGB3 (0.36) | EDNRAEDNRBITGB3ITGAVALDH1A1 | |
| SCHEMBL8708878 | 0.86 | LARS1 (0.43) | ITGB3ITGAVTP53GHSR | |
| SCHEMBL8711054 | 0.85 | EDNRA (0.49) | EDNRAEDNRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050014769-A1 | Use of endothelin receptor antogonists for the treatment of tumour diseases | MERCK PATENT GMBH (DE) | 2005-01-20 | — | — | US | claimed |
| US-20050014769-A1 | Use of endothelin receptor antogonists for the treatment of tumour diseases | MERCK PATENT GMBH (DE) | 2005-01-20 | — | — | US | disclosed |
| WO-1998041515-A1 | ENDOTHOLIN RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 1998-09-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014769-A1 | Use of endothelin receptor antogonists for the treatment of tumour diseases | EDNRA, EDNRB, ECE1 | TDP1 3562/4885EDNRA 1/4885EDNRB 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.