SCHEMBL8710102

SCHEMBL8710102

CC(C)(C)c1ccc(S(=O)(=O)NC(=O)C(Cc2ccc(C(=O)O)cc2)c2ccc3nsnc3c2)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 2/20 0.42
MEN1 O00255 3/20 0.41
KMT2A Q03164 3/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
L3MBTL1 Q9Y468 3/20 0.41
ALDH1A1 P00352 3/20 0.41
MAPT P10636 1/20 0.41
HDAC3 O15379 1/20 0.39
HDAC8 Q9BY41 1/20 0.39
HDAC6 Q9UBN7 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
NR1H4 Q96RI1 2/20 0.39
GCGR P47871 5/20 0.39
ADCY6 O43306 3/20 0.39
ADCY3 O60266 3/20 0.39
ADCY9 O60503 3/20 0.39
ADCY5 O95622 3/20 0.39
ADCY8 P40145 3/20 0.39
ADCY7 P51828 3/20 0.39
ADCY2 Q08462 3/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8705691 0.92 MAPT (0.50) EPHX2MEN1KMT2ASMN1; SMN2ALDH1A1
SCHEMBL8709132 0.92 EPHX2 (0.41) EPHX2MEN1KMT2ASMN1; SMN2ALDH1A1
SCHEMBL8705052 0.91 MEN1 (0.45) EPHX2MEN1KMT2ASMN1; SMN2ALDH1A1
SCHEMBL8705303 0.91 MAPT (0.40) EPHX2MEN1KMT2ASMN1; SMN2ALDH1A1
SCHEMBL6322172 0.91 TDP1 (0.40) MEN1KMT2ASMN1; SMN2L3MBTL1ALDH1A1
SCHEMBL8709538 0.90 NR1H4 (0.42) EPHX2MEN1KMT2ASMN1; SMN2ALDH1A1
SCHEMBL8709894 0.90 FLT1 (0.44) EPHX2MEN1KMT2ASMN1; SMN2ALDH1A1
SCHEMBL8709556 0.88 MEN1 (0.43) EPHX2MEN1KMT2ASMN1; SMN2L3MBTL1
SCHEMBL8709156 0.88 EPHX2 (0.39) EPHX2MEN1KMT2ASMN1; SMN2ALDH1A1
SCHEMBL8709789 0.86 MEN1 (0.39) EPHX2MEN1KMT2ASMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1998041515-A1 ENDOTHOLIN RECEPTOR ANTAGONISTS MERCK PATENT GMBH (DE) 1998-09-24 WO disclosed