SCHEMBL632230

SCHEMBL632230

Nc1cccc(-n2cccc2)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 1.00
ALDH1A1 P00352 4/20 0.52
KDM4E B2RXH2 4/20 0.52
CASP1 P29466 2/20 0.52
MEN1 O00255 2/20 0.52
KMT2A Q03164 2/20 0.52
ALOX15 P16050 1/20 0.52
CASP7 P55210 1/20 0.52
CYP3A4 P08684 1/20 0.50
RECQL P46063 1/20 0.50
ADRA2C P18825 1/20 0.48
AOC2 O75106 2/20 0.47
DDB1 Q16531 1/20 0.42
CRBN Q96SW2 1/20 0.42
LMNA P02545 1/20 0.41
USP2 O75604 1/20 0.41
KEAP1 Q14145 1/20 0.41
NFE2L2 Q16236 1/20 0.41
CA12 O43570 1/20 0.41
CA1 P00915 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20319187 0.82 MAPT (0.68) MAPTALDH1A1KDM4EMEN1KMT2A
SCHEMBL1354158 0.77 MAPT (0.63) MAPTALDH1A1KDM4ECASP1MEN1
SCHEMBL30341093 0.77 MAPT (0.63) MAPTALDH1A1KDM4ECASP1MEN1
SCHEMBL632660 0.76 IDO1 (0.64) MAPTMEN1KMT2AALOX15CYP3A4
SCHEMBL10207531 0.76 MAPT (0.60) MAPTALDH1A1KDM4ECASP1MEN1
SCHEMBL26185698 0.73 ADRA2C (0.61) MAPTALDH1A1KDM4ECASP1MEN1
SCHEMBL6942579 0.73 ADRA2C (0.80) MAPTALDH1A1KDM4ECASP1MEN1
SCHEMBL2091291 0.73 MAPT (0.57) MAPTALDH1A1KDM4ERECQLAOC2
Amphenidone SCHEMBL586236 0.73 MAPT (0.57) MAPTALDH1A1KDM4ECASP1MEN1
SCHEMBL296099 0.72 MAPT (0.56) MAPTALDH1A1KDM4EMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 111 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10566106-B2 Conjugated polymer coatings and methods for atmospheric plasma deposition thereof THE BOEING COMPANY (US) 2020-02-18 US claimed
US-20160049226-A1 CONJUGATED POLYMER COATINGS AND METHODS FOR ATMOSPHERIC PLASMA DEPOSITION THEREOF THE BOEING COMPANY 2016-02-18 US claimed
US-20100256132-A1 IL-12 MODULATORY COMPOUNDS SYNTA PHARMACEUTICALS CORPORATION (US) 2010-10-07 US claimed
US-20080207694-A1 Hydroxamates as Histone Deacetylase Inhibitors and Pharmaceutical Formulations Containing Them ROSSI CRISTINA 2008-08-28 US claimed
EP-1868997-A1 HYDROXAMATES AS HISTONE DEACETYLASE INHIBITORS AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM Menarini International Operations Luxembourg S.A. (LU) 2007-12-26 EP claimed
EP-1819341-A2 IL-12 MODULATORY COMPOUNDS Synta Pharmaceuticals Corporation (US) 2007-08-22 EP claimed
US-20060223996-A1 IL-12 modulatory compounds SYNTA PHARMACEUTICALS CORP. (US) 2006-10-05 US claimed
WO-2006097460-A1 HYDROXAMATES AS HISTONE DEACETYLASE INHIBITORS AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A. (LU) 2006-09-21 WO claimed
WO-2006053227-A2 IL-12 MODULATORY COMPOUNDS SYNTA PHARMACEUTICALS CORP. (US) 2006-05-18 WO claimed
US-20250282736-A1 SMALL MOLECULE MODULATORS OF HUMAN PREGNANE X RECEPTOR ST JUDE CHILDRENS RES HOSPITAL (US) 2025-09-11 US disclosed
US-12391781-B2 Black particles, black coating material, coating film, and black matrix for color filters SEKISUI CHEMICAL CO., LTD. (JP) 2025-08-19 US disclosed
EP-4063426-B1 BLACK PARTICLES, BLACK COATING MATERIAL, COATING FILM, AND BLACK MATRIX FOR COLOR FILTERS SEKISUI CHEMICAL CO LTD (JP) 2025-06-18 EP disclosed
EP-4157844-B1 4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-3,6-DIHYDROPYRIDINE-1-(2H)-CARBOXAMIDE DERIVATIVES AS LIMK AND/OR ROCK KINASES INHIBITORS FOR USE IN THE TREATMENT OF CANCER CENTRE NAT RECH SCIENT (FR) 2024-07-10 EP disclosed
CN-114502677-B Black particles, black paint, coating film, and black matrix for color filter 积水化学工业株式会社 2023-11-14 CN disclosed
EP-1164134-A1 Benzimidazole compounds and their use as modulators of the GABA A receptor complex NEUROSEARCH A/S (DK) 2001-12-19 EP disclosed
EP-0821684-B1 BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABA A? RECEPTOR COMPLEX NEUROSEARCH AS (DK) 2001-12-05 EP disclosed
US-5922724-A Benzimidazole compounds and their use as modulators of the GABA a receptor complex NEUROSEARCH A/S (DK) 1999-07-13 US disclosed
EP-0821684-A1 BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABA A? RECEPTOR COMPLEX NEUROSEARCH A/S (DK) 1998-02-04 EP disclosed
WO-1996033194-A1 BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABA A RECEPTOR COMPLEX NEUROSEARCH A/S (DK) 1996-10-24 WO disclosed
US-4617316-A Insecticidal heteroaryl substituted phenyl benzoylureas FMC CORPORATION (US) 1986-10-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060223996-A1 IL-12 modulatory compounds IL2, IL4, IFNG MAPT 3259/4885ALDH1A1 1381/4885KDM4E 3666/4885
US-20080207694-A1 Hydroxamates as Histone Deacetylase Inhibitors and Pharmaceutical Formulations Containing Them HDAC1, HDAC8, HDAC9 MAPT 791/4885ALDH1A1 1106/4885KDM4E 183/4885
US-20250282736-A1 SMALL MOLECULE MODULATORS OF HUMAN PREGNANE X RECEPTOR NR1H4, NR1I2, NR1I3 MAPT 3783/4885ALDH1A1 3469/4885KDM4E 4050/4885
US-20100256132-A1 IL-12 MODULATORY COMPOUNDS IL2, IL4, IFNG MAPT 3259/4885ALDH1A1 1381/4885KDM4E 3666/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.