Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.46 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.46 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.46 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3290264 | 0.83 | ALDH1A1 (0.53) | TSHRMAPK1ALDH1A1MEN1KMT2A | |
| SCHEMBL7185413 | 0.80 | PDE4A (0.65) | TSHRMAPK1ALDH1A1KDM4EHPGD | |
| SCHEMBL9536041 | 0.77 | NPC1 (0.46) | TSHRMAPK1ALDH1A1KMT2AKDM4E | |
| SCHEMBL3293573 | 0.76 | CSF1R (0.44) | TSHRMAPK1ALDH1A1MEN1KMT2A | |
| SCHEMBL5101006 | 0.76 | NR4A2 (0.59) | TSHRALDH1A1KDM4ENPC1LMNA | |
| SCHEMBL16088470 | 0.76 | CSF1R (0.44) | TSHRMAPK1ALDH1A1MEN1KMT2A | |
| SCHEMBL28537798 | 0.76 | CSF1R (0.62) | NPC1MAPT | |
| SCHEMBL28526527 | 0.75 | NPSR1 (0.60) | TSHRMAPK1ALDH1A1MEN1KMT2A | |
| SCHEMBL4583739 | 0.74 | CSF1R (0.46) | TSHRMAPK1ALDH1A1MEN1KMT2A | |
| SCHEMBL18312911 | 0.73 | TDP1 (0.47) | TSHRMAPK1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6900205-B2 | 1,8-Naphthyridine derivatives and their use to treat diabetes and related disorders | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-05-31 | — | — | US | disclosed |