Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.41 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 4/20 | 0.39 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | CA9 | Q16790 | 3/20 | 0.39 |
| ▸ | CA7 | P43166 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TGM2 | P21980 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6322869 | 1.00 | ALDH1A1 (0.41) | ALDH1A1ALDH2ALDH3A1CA1CA2 | |
| SCHEMBL9472887 | 0.83 | CA1 (0.37) | ALDH1A1ALDH2ALDH3A1CA1CA2 | |
| SCHEMBL9472891 | 0.83 | CA1 (0.37) | ALDH1A1ALDH2ALDH3A1CA1CA2 | |
| SCHEMBL6317230 | 0.79 | SMN1; SMN2 (0.43) | ALDH1A1ALDH2ALDH3A1CA1CA2 | |
| SCHEMBL6317225 | 0.79 | SMN1; SMN2 (0.43) | ALDH1A1ALDH2ALDH3A1CA1CA2 | |
| SCHEMBL6323908 | 0.79 | S100A4 (0.40) | ALDH1A1GABRA1GABRA2NPSR1LMNA | |
| SCHEMBL6323909 | 0.79 | S100A4 (0.40) | ALDH1A1GABRA1GABRA2NPSR1LMNA | |
| SCHEMBL4739821 | 0.76 | IDO1 (0.53) | ALDH1A1CA1CA2CA9LRRK2 | |
| SCHEMBL4739822 | 0.76 | IDO1 (0.53) | ALDH1A1CA1CA2CA9LRRK2 | |
| SCHEMBL29870149 | 0.76 | ALDH1A1 (0.67) | ALDH1A1ALDH2ALDH3A1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120190009-A1 | Viral Modulators and Processes Thereof | KASHANCHI FATAH (US) | 2012-07-26 | — | — | US | claimed |
| US-6969729-B2 | Use of isatin derivatives as ion channel activating agents | NEUROSEARCH A/S (DK) | 2005-11-29 | — | — | US | claimed |
| US-20030114513-A1 | Use of isatin derivatives as ion channel activating agents | NEUROSEARCH A/S | 2003-06-19 | — | — | US | claimed |
| US-20120190723-A1 | VIRAL MODULATORS AND PROCESSES THEREOF | KASHANCHI FATAH (US) | 2012-07-26 | — | — | US | disclosed |
| US-20120190723-A1 | VIRAL MODULATORS AND PROCESSES THEREOF | KASHANCHI FATAH (US) | 2012-07-26 | — | — | US | disclosed |
| US-20120190009-A1 | Viral Modulators and Processes Thereof | KASHANCHI FATAH (US) | 2012-07-26 | — | — | US | disclosed |
| US-20120190009-A1 | Viral Modulators and Processes Thereof | KASHANCHI FATAH (US) | 2012-07-26 | — | — | US | disclosed |
| US-20120190723-A1 | VIRAL MODULATORS AND PROCESSES THEREOF | KASHANCHI FATAH (US) | 2012-07-26 | — | — | US | disclosed |
| US-20120190009-A1 | Viral Modulators and Processes Thereof | KASHANCHI FATAH (US) | 2012-07-26 | — | — | US | disclosed |
| US-6969729-B2 | Use of isatin derivatives as ion channel activating agents | NEUROSEARCH A/S (DK) | 2005-11-29 | — | — | US | disclosed |
| US-20030114513-A1 | Use of isatin derivatives as ion channel activating agents | NEUROSEARCH A/S | 2003-06-19 | — | — | US | disclosed |
| EP-0432648-B1 | Isatine derivatives, their preparation and use | NEUROSEARCH AS (DK) | 1995-08-02 | — | — | EP | disclosed |
| US-5198461-A | Isatine derivatives, their preparation and use | NEUROSEARCH A/S (DK) | 1993-03-30 | — | — | US | disclosed |
| EP-0432648-A2 | Isatine derivatives, their preparation and use | NEUROSEARCH A/S (DK) | 1991-06-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030114513-A1 | Use of isatin derivatives as ion channel activating agents | KCNN3, KCNJ2, KCND2 | ALDH1A1 3865/4885ALDH2 1075/4885ALDH3A1 2381/4885 |
| US-20120190723-A1 | VIRAL MODULATORS AND PROCESSES THEREOF | MAVS, HAVCR2, HDLBP | ALDH1A1 4453/4885ALDH2 4196/4885ALDH3A1 4177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.