Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.47 |
| ▸ | ENPP3 | O14638 | 3/20 | 0.43 |
| ▸ | ALPL | P05186 | 3/20 | 0.43 |
| ▸ | XIAP | P98170 | 3/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3895806 | 0.80 | TSHR (0.55) | SMN1; SMN2ALDH1A1CA12CA1CA2 | |
| SCHEMBL946095 | 0.79 | TSHR (0.48) | LMNAHPGDMAPTALDH1A1P2RX4 | |
| SCHEMBL31068112 | 0.78 | HPGD (0.52) | HPGDCA12CA1CA2CA7 | |
| SCHEMBL1892160 | 0.77 | TSHR (0.47) | LMNAHPGDMAPTALDH1A1P2RX4 | |
| Methyl Alcohol SCHEMBL27278041 | 0.76 | TSHR (0.46) | LMNAHPGDMAPTALDH1A1P2RX4 | |
| SCHEMBL25931829 | 0.75 | CYP19A1 (0.55) | LMNAMEN1KMT2AHPGDHTT | |
| SCHEMBL7588496 | 0.74 | HPGD (0.56) | MEN1KMT2AHPGDSMN1; SMN2MAPT | |
| SCHEMBL6325746 | 0.72 | CES1 (0.57) | HPGDSMN1; SMN2ALDH1A1P2RX4CA12 | |
| SCHEMBL20261717 | 0.71 | CA12 (0.73) | LMNAMEN1KMT2AHPGDHTT | |
| SCHEMBL27386714 | 0.71 | L3MBTL1 (0.42) | LMNAHPGDSMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050124664-A1 | Urea thiadiazole inhibitors of plasminogen activator inhibior-1 | BRISTOL-MYERS SQUIBB CO. | 2005-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124664-A1 | Urea thiadiazole inhibitors of plasminogen activator inhibior-1 | SERPINE1, SERPINC1, SERPINB1 | LMNA 1497/4885MEN1 1004/4885KMT2A 4128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.