Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 14/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL745777 | 0.78 | DYRK1A (0.51) | GRM5KCNH2FGFR1DYRK1A | |
| SCHEMBL6791706 | 0.77 | GRM5 (0.51) | GRM5 | |
| SCHEMBL20641223 | 0.76 | GRM5 (0.51) | GRM5DYRK1A | |
| SCHEMBL14421510 | 0.73 | DYRK1A (0.47) | GRM5KCNH2FGFR1DYRK1A | |
| SCHEMBL29902888 | 0.73 | DYRK1A (0.47) | GRM5KCNH2FGFR1DYRK1A | |
| SCHEMBL20641235 | 0.73 | MAP3K14 (0.50) | GRM5DYRK1A | |
| SCHEMBL4562631 | 0.72 | KCNH2 (0.67) | GRM5KCNH2MAOB | |
| SCHEMBL30707869 | 0.72 | KCNH2 (0.67) | GRM5KCNH2MAOB | |
| SCHEMBL18041745 | 0.70 | TGFBR1 (0.54) | FGFR1DYRK1A | |
| Charcoal, Activated SCHEMBL31286308 | 0.70 | KCNH2 (0.64) | GRM5KCNH2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050014938-A1 | Phenyl substituted triazoles and their use as selective inhibitors of akl5 kinase | GASTER LARAMIE MARY (GB) | 2005-01-20 | — | — | US | disclosed |
| EP-1444232-A1 | PHENYL SUBSTITUTED TRIAZOLES AND THEIR USE AS SELECTIVE INHIBORS OF AKL5 KINASE | SMITHKLINE BEECHAM CORPORATION (US) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003042211-A1 | PHENYL SUBSTITUTED TRIAZOLES AND THEIR USE AS SELECTIVE INHIBORS OF AKL5 KINASE | SMITHKLINE BEECHAM CORPORATION (US) | 2003-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014938-A1 | Phenyl substituted triazoles and their use as selective inhibitors of akl5 kinase | AKR1C3, CBR3, PHKG1 | GRM5 1589/4885KCNH2 64/4885MAOB 1211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.