Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6332378 | 0.83 | ALDH1A1 (0.41) | CHRNA7CYP2D6CYP1A2ALDH1A1NPSR1 | |
| SCHEMBL1791683 | 0.83 | GHSR (0.42) | CHRNA7KCNH2CYP2D6CYP1A2 | |
| SCHEMBL928166 | 0.81 | NPC1 (0.37) | CHRNA7CYP2D6CYP1A2ALDH1A1SMN1; SMN2 | |
| SCHEMBL928324 | 0.81 | USP30 (0.36) | CHRNA7CYP2D6CYP1A2ALDH1A1CYP3A4 | |
| SCHEMBL6324081 | 0.77 | CHRNA7 (0.46) | CHRNA7KCNH2HCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL1797114 | 0.76 | KCNH2 (0.44) | CHRNA7KCNH2ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL1792649 | 0.74 | CHRNA7 (0.39) | CHRNA7CYP2D6CYP1A2 | |
| SCHEMBL1792193 | 0.72 | CHRNB2 (0.39) | CHRNA7KCNH2ALDH1A1KDM4EMAPK1 | |
| SCHEMBL926714 | 0.72 | CHRNA7 (0.53) | CHRNA7KCNH2ACACBHCRTR1HCRTR2 | |
| SCHEMBL1793090 | 0.72 | CHRNA7 (0.53) | CHRNA7KCNH2ACACBHCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050065178-A1 | Substituted diazabicycloakane derivatives | ABBOTT LABORATORIES | 2005-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065178-A1 | Substituted diazabicycloakane derivatives | CHRNA7, CHRNA1, CHRNA5 | CHRNA7 1/4885KCNH2 179/4885ACACB 757/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.