SCHEMBL1797114

SCHEMBL1797114

Cc1ccc(S(=O)(=O)OC2C3CN(c4ccc(-c5ccc6ccccc6c5)nc4)CC3CN2C)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 1/20 0.44
CHRNA7 P36544 3/20 0.41
CHRNB2 P17787 2/20 0.41
CHRNA4 P43681 2/20 0.41
MMP2 P08253 1/20 0.37
MMP9 P14780 1/20 0.37
LMNA P02545 2/20 0.36
HTT P42858 2/20 0.36
PKM P14618 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
HDAC3 O15379 2/20 0.36
HDAC4 P56524 2/20 0.36
HDAC1 Q13547 2/20 0.36
HDAC7 Q8WUI4 2/20 0.36
HDAC2 Q92769 2/20 0.36
HDAC10 Q969S8 2/20 0.36
HDAC11 Q96DB2 2/20 0.36
HDAC8 Q9BY41 2/20 0.36
HDAC6 Q9UBN7 2/20 0.36
HDAC9 Q9UKV0 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1792193 0.84 CHRNB2 (0.39) KCNH2CHRNA7CHRNB2CHRNA4MEN1
SCHEMBL1802907 0.83 CHRNB2 (0.38) KCNH2CHRNA7CHRNB2CHRNA4
SCHEMBL6332378 0.80 ALDH1A1 (0.41) CHRNA7CHRNB2CHRNA4MEN1ALDH1A1
SCHEMBL1797112 0.80 CHRNB2 (0.54) KCNH2CHRNA7CHRNB2CHRNA4MMP2
SCHEMBL1791683 0.78 GHSR (0.42) KCNH2CHRNA7PTGS2
SCHEMBL6324089 0.76 CHRNA7 (0.40) KCNH2CHRNA7SMN1; SMN2MEN1ALDH1A1
SCHEMBL1792844 0.75 CHRNB2 (0.43) CHRNA7CHRNB2CHRNA4SMN1; SMN2ALDH1A1
SCHEMBL928578 0.74 CHRNA7 (0.72) KCNH2CHRNA7CHRNB2CHRNA4
SCHEMBL928324 0.73 USP30 (0.36) CHRNA7HDAC3HDAC4HDAC1HDAC7
SCHEMBL928166 0.71 NPC1 (0.37) CHRNA7HTTSMN1; SMN2MEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2316836-A1 Substituted diazabicycloalkane derivatives as ligands at alpha 7 nicotinic acetylcholine receptors Abbott Laboratories (US) 2011-05-04 EP disclosed