Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 18/20 | 0.60 |
| ▸ | TNKS | O95271 | 1/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.54 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.54 |
| ▸ | PARP6 | Q2NL67 | 1/20 | 0.54 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.54 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.54 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.54 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.54 |
| ▸ | PARP8 | Q8N3A8 | 1/20 | 0.54 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.54 |
| ▸ | PARP12 | Q9H0J9 | 1/20 | 0.54 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.54 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.54 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.54 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.54 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.54 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.49 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6328650 | 0.82 | PARP1 (0.57) | PARP1 | |
| SCHEMBL25307211 | 0.76 | PARP1 (0.56) | PARP1TNKSADORA1CDK6PDE3A | |
| SCHEMBL8271262 | 0.74 | PARP1 (0.74) | PARP1TNKSADORA1CDK6PDE3A | |
| SCHEMBL22852727 | 0.73 | PARP1 (0.98) | PARP1TNKSADORA1CDK6PDE3A | |
| SCHEMBL11413405 | 0.72 | PARP1 (0.70) | PARP1PRMT5 | |
| SCHEMBL19569946 | 0.72 | PARP1 (0.93) | PARP1TNKSADORA1CDK6PDE3A | |
| SCHEMBL15918118 | 0.72 | PARP1 (0.71) | PARP1TNKSADORA1CDK6PDE3A | |
| SCHEMBL15917820 | 0.72 | PARP1 (0.73) | PARP1TNKSADORA1CDK6PDE3A | |
| SCHEMBL5160196 | 0.71 | LMNA (0.57) | PARP1PRMT5 | |
| SCHEMBL6327914 | 0.71 | MAPT (0.56) | PARP1TNKSTNKS2PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6924284-B2 | PARP inhibitors | ICOS CORPORATION (US) | 2005-08-02 | — | — | US | disclosed |