Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 16/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6324300 | 0.82 | PARP1 (0.60) | PARP1 | |
| SCHEMBL6327914 | 0.77 | MAPT (0.56) | PARP1KMT2AROCK2ROCK1SMN1; SMN2 | |
| SCHEMBL6334598 | 0.76 | LMNA (0.62) | PARP1SMN1; SMN2 | |
| SCHEMBL6328130 | 0.74 | TSHR (0.68) | PARP1SMN1; SMN2 | |
| SCHEMBL11413405 | 0.74 | PARP1 (0.70) | PARP1KMT2A | |
| SCHEMBL5160196 | 0.73 | LMNA (0.57) | PARP1KMT2ASMN1; SMN2 | |
| SCHEMBL6324019 | 0.71 | MAPT (0.59) | PARP1KMT2AROCK2ROCK1SMN1; SMN2 | |
| SCHEMBL25307211 | 0.69 | PARP1 (0.56) | PARP1KMT2A | |
| SCHEMBL2841801 | 0.69 | ALDH1A1 (0.68) | KMT2ASMN1; SMN2 | |
| SCHEMBL17444762 | 0.68 | SMN1; SMN2 (0.52) | PARP1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6924284-B2 | PARP inhibitors | ICOS CORPORATION (US) | 2005-08-02 | — | — | US | disclosed |