Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | PARP1 | P09874 | 6/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | TNKS | O95271 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6324019 | 0.97 | MAPT (0.59) | MAPTALDH1A1TSHRHTTLMNA | |
| SCHEMBL6334598 | 0.94 | LMNA (0.62) | MAPTALDH1A1TSHRHTTLMNA | |
| SCHEMBL6328130 | 0.91 | TSHR (0.68) | MAPTALDH1A1TSHRHTTLMNA | |
| SCHEMBL6326044 | 0.90 | MAPT (0.56) | MAPTALDH1A1TSHRHTTLMNA | |
| SCHEMBL6324067 | 0.88 | MAPT (0.72) | MAPTALDH1A1TSHRHTTLMNA | |
| SCHEMBL6332641 | 0.86 | PARP1 (0.47) | MAPTALDH1A1TSHRHTTLMNA | |
| SCHEMBL6331273 | 0.83 | MAPT (0.48) | MAPTALDH1A1TSHRHTTLMNA | |
| SCHEMBL6328650 | 0.77 | PARP1 (0.57) | PARP1KMT2AROCK2ROCK1SMN1; SMN2 | |
| SCHEMBL6325619 | 0.76 | CYP1A2 (0.58) | MAPTALDH1A1TSHRHTTLMNA | |
| SCHEMBL6328504 | 0.71 | HCRTR1 (0.46) | MAPTALDH1A1TSHRHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6924284-B2 | PARP inhibitors | ICOS CORPORATION (US) | 2005-08-02 | — | — | US | disclosed |