Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15132316 | 0.78 | — | — | |
| SCHEMBL8909609 | 0.76 | — | — | |
| SCHEMBL16193449 | 0.74 | — | — | |
| SCHEMBL11291367 | 0.72 | CA2 (0.41) | CA2CA9 | |
| SCHEMBL11652838 | 0.71 | TSHR (0.34) | — | |
| SCHEMBL17542306 | 0.70 | CA2 (0.35) | CA2CA9 | |
| SCHEMBL17542461 | 0.70 | CA2 (0.35) | CA2CA9 | |
| SCHEMBL17542303 | 0.70 | CA2 (0.35) | CA2CA9 | |
| SCHEMBL3096305 | 0.70 | — | — | |
| SCHEMBL16428196 | 0.69 | ALDH1A1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6894045-B2 | Tetrahydropurinones and derivatives thereof as corticotropin releasing factor receptor ligands | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2005-05-17 | — | — | US | disclosed |
| US-20030149059-A1 | Tetrahydropurinones and derivatives thereof as corticotropin releasing factor receptor ligands | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2003-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030149059-A1 | Tetrahydropurinones and derivatives thereof as corticotropin releasing factor receptor ligands | CRH, CRHR1, CRHR2 | CA2 4745/4885CA9 4810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.