Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROR1 | Q01973 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CBS | P35520 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2491951 | 0.88 | ROR1 (0.39) | ROR1ALDH1A1NPSR1LMNAKDM4E | |
| SCHEMBL30725970 | 0.84 | ALDH1A1 (0.58) | ROR1ALDH1A1MEN1HTTKMT2A | |
| SCHEMBL10054661 | 0.84 | ALDH1A1 (0.58) | ROR1ALDH1A1MEN1HTTKMT2A | |
| SCHEMBL6324673 | 0.84 | ALDH1A1 (0.58) | ROR1ALDH1A1MEN1HTTKMT2A | |
| SCHEMBL5788017 | 0.81 | ALDH1A1 (0.46) | ROR1ALDH1A1MEN1HTTKMT2A | |
| SCHEMBL5791797 | 0.81 | ALDH1A1 (0.47) | ROR1ALDH1A1MEN1HTTKMT2A | |
| SCHEMBL15077679 | 0.77 | ALDH1A1 (0.47) | ROR1ALDH1A1MEN1HTTKMT2A | |
| SCHEMBL15077681 | 0.77 | ALDH1A1 (0.47) | ROR1ALDH1A1MEN1HTTKMT2A | |
| SCHEMBL2629461 | 0.76 | ALDH1A1 (0.55) | ALDH1A1MAPTABCB1CYP3A4CYP19A1 | |
| SCHEMBL30966448 | 0.76 | ALDH1A1 (0.55) | ALDH1A1MAPTABCB1CYP3A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6943182-B2 | Cyclopentabenzofuran derivatives and their use | BAYER AKTIENGESELLSCHAFT (DE) | 2005-09-13 | — | — | US | disclosed |
| US-20030144334-A1 | Cyclopentabenzofuran derivatives and their use | GUARNIERI WALTER (DE) | 2003-07-31 | — | — | US | disclosed |
| EP-1102761-B1 | CYCLOPENTABENZOFURAN DERIVATIVES AND THEIR USE | BAYER AG (DE) | 2003-01-29 | — | — | EP | disclosed |
| US-6420393-B1 | NUCLEAR FACTOR .KAPPA.B-DEPENDENT DISEASE SELECTED FROM THE GROUP CONSISTING OF INFLAMMATORY DISEASES, IMMUNOLOGICAL DISORDERS, SEPTIC SHOCK, TRANSPLANT REJECTION, RADIATION DAMAGE, REPERFUSION INJURIES AFTER ISCHEMIA, STROKE OR | BAYER AKTIENGESELLSCHAFT (DE) | 2002-07-16 | — | — | US | disclosed |
| EP-1102761-A2 | CYCLOPENTABENZOFURAN DERIVATIVES AND THEIR USE | Bayer Aktiengesellschaft (DE) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000008007-A2 | CYCLOPENTABENZOFURAN DERIVATIVES AND THEIR USE | BAYER AKTIENGESELLSCHAFT (DE) | 2000-02-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030144334-A1 | Cyclopentabenzofuran derivatives and their use | NFKBIA, IKBKG, NFKB1 | ROR1 3665/4885ALDH1A1 2159/4885MEN1 4057/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.