Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.67 |
| ▸ | RAB9A | P51151 | 5/20 | 0.67 |
| ▸ | MEN1 | O00255 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | HPGD | P15428 | 4/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | GFER | P55789 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | CASP3 | P42574 | 2/20 | 0.54 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.54 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29941469 | 1.00 | NPC1 (0.67) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL8304969 | 0.87 | NPC1 (0.80) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL8690359 | 0.85 | RAB9A (0.66) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL29804733 | 0.85 | RAB9A (0.66) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL28461746 | 0.81 | NPC1 (0.78) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL29804862 | 0.81 | RAB9A (0.71) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL3986163 | 0.81 | RAB9A (0.71) | NPC1RAB9AMEN1KMT2AKDM4E | |
| 2-Phenyl-1H-Indole SCHEMBL341378 | 0.81 | NPC1 (1.00) | NPC1RAB9AMEN1KMT2AKDM4E | |
| 2-Phenyl-1H-Indole SCHEMBL29363616 | 0.81 | NPC1 (1.00) | NPC1RAB9AMEN1KMT2AKDM4E | |
| 2-Phenyl-1H-Indole SCHEMBL6529483 | 0.79 | NPC1 (0.96) | NPC1RAB9AMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115304533-B | Bisindolemethane type alpha-glucosidase inhibitor and preparation method and application thereof | 中国医学科学院药用植物研究所云南分所 | 2024-04-12 | — | — | CN | disclosed |
| CN-117567447-A | Thiophene-containing bis-indolomethane type a-glucosidase inhibitor and preparation method and application thereof | 中国医学科学院药用植物研究所云南分所 | 2024-02-20 | — | — | CN | disclosed |
| CN-115304533-A | Bis-indole methane type alpha-glucosidase inhibitor and preparation method and application thereof | 中国医学科学院药用植物研究所云南分所 | 2022-11-08 | — | — | CN | disclosed |
| CN-111087391-A | 4-indole quinazoline compound and preparation method and application thereof | 郑州大学 | 2020-05-01 | — | — | CN | disclosed |
| US-20190192691-A1 | REGULATED BIOCIRCUIT SYSTEMS | OBSIDIAN THERAPEUTICS, INC. | 2019-06-27 | — | — | US | disclosed |
| US-6894079-B1 | Method for reducing free-radical induced injury | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | 2005-05-17 | — | — | US | disclosed |
| WO-2000032181-A9 | METHOD FOR REDUCING FREE-RADICAL INDUCED INJURY | ROTTA ALEXANDRE T (US) | 2002-04-11 | — | — | WO | disclosed |
| EP-1135114-A4 | METHOD FOR REDUCING FREE-RADICAL INDUCED INJURY | ROTTA ALEXANDRE T (US) | 2002-01-02 | — | — | EP | disclosed |
| EP-1135114-A1 | METHOD FOR REDUCING FREE-RADICAL INDUCED INJURY | Rotta, Alexandre T. (US) | 2001-09-26 | — | — | EP | disclosed |
| WO-2000032181-A1 | METHOD FOR REDUCING FREE-RADICAL INDUCED INJURY | ROTTA ALEXANDRE T (US) | 2000-06-08 | — | — | WO | disclosed |