Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 17/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.53 |
| ▸ | HSD11B2 | P80365 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12308304 | 0.87 | HSD11B1 (0.60) | HSD11B1EPHX2HSD11B2 | |
| SCHEMBL230322 | 0.84 | HSD11B1 (0.57) | HSD11B1EPHX2HSD11B2 | |
| SCHEMBL232571 | 0.84 | HSD11B1 (0.57) | HSD11B1EPHX2HSD11B2 | |
| SCHEMBL28067782 | 0.81 | HSD11B1 (0.54) | HSD11B1EPHX2HSD11B2 | |
| SCHEMBL6344160 | 0.80 | EPHX2 (0.58) | HSD11B1EPHX2LMNAHTT | |
| SCHEMBL12334440 | 0.78 | HSD11B1 (0.56) | HSD11B1EPHX2HSD11B2 | |
| SCHEMBL257525 | 0.78 | HSD11B1 (0.56) | HSD11B1EPHX2HSD11B2 | |
| SCHEMBL231998 | 0.77 | HSD11B1 (0.70) | HSD11B1EPHX2HSD11B2 | |
| SCHEMBL3041989 | 0.76 | HSD11B1 (0.54) | HSD11B1EPHX2HSD11B2 | |
| SCHEMBL14697321 | 0.76 | HSD11B1 (0.54) | HSD11B1EPHX2HSD11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050245534-A1 | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme | ABBOTT LABORATORIES | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245534-A1 | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme | HSD11B1, HSD17B1, HSD11B2 | HSD11B1 1/4885EPHX2 643/4885HSD11B2 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.