Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 8/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12919905 | 0.84 | EPHX2 (0.61) | EPHX2L3MBTL1HSD17B10EPHX1HSD11B1 | |
| SCHEMBL10421594 | 0.81 | EPHX2 (0.58) | EPHX2L3MBTL1HSD17B10EPHX1HSD11B1 | |
| SCHEMBL6325458 | 0.80 | HSD11B1 (0.57) | EPHX2HSD11B1LMNAHTT | |
| SCHEMBL10768733 | 0.77 | EPHX2 (0.57) | EPHX2L3MBTL1HSD17B10EPHX1HSD11B1 | |
| SCHEMBL10768735 | 0.77 | EPHX2 (0.57) | EPHX2L3MBTL1HSD17B10EPHX1HSD11B1 | |
| SCHEMBL10522471 | 0.73 | EPHX2 (0.49) | EPHX2L3MBTL1HSD17B10EPHX1HSD11B1 | |
| SCHEMBL10522466 | 0.73 | EPHX2 (0.49) | EPHX2L3MBTL1HSD17B10EPHX1HSD11B1 | |
| SCHEMBL1223956 | 0.73 | L3MBTL1 (0.57) | EPHX2L3MBTL1HSD17B10EPHX1HSD11B1 | |
| SCHEMBL3069167 | 0.72 | EPHX2 (0.70) | EPHX2L3MBTL1HSD17B10EPHX1HSD11B1 | |
| SCHEMBL6336061 | 0.71 | HSD11B1 (0.52) | EPHX2L3MBTL1HSD17B10EPHX1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050261302-A1 | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their therapeutic application | ABBOTT LABORATORIES | 2005-11-24 | — | — | US | disclosed |
| US-20050245533-A1 | Inhibitors of the 11-beta-hydroxysteroid dehydrogenaseType 1 enzyme and their therapeutic application | ABBOTT LABORATORIES | 2005-11-03 | — | — | US | disclosed |
| US-20050245532-A1 | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their therapeutic application | ABBOTT LABORATORIES | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245532-A1 | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their therapeutic application | HSD11B1, HSD17B1, HSD3B1 | EPHX2 696/4885L3MBTL1 2687/4885HSD17B10 11/4885 |
| US-20050245533-A1 | Inhibitors of the 11-beta-hydroxysteroid dehydrogenaseType 1 enzyme and their therapeutic application | HSD11B1, HSD17B1, HSD3B1 | EPHX2 676/4885L3MBTL1 2382/4885HSD17B10 11/4885 |
| US-20050261302-A1 | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their therapeutic application | HSD11B1, HSD17B1, HSD3B1 | EPHX2 696/4885L3MBTL1 2687/4885HSD17B10 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.