Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA3 | P07451 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | CA6 | P23280 | 1/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.42 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.41 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12316477 | 0.85 | ERN1 (0.54) | ERN1KDM4EALDH1A1GAALMNA | |
| SCHEMBL4868587 | 0.85 | AKR1C4 (0.58) | ERN1KDM4EALDH1A1GAALMNA | |
| SCHEMBL6331461 | 0.84 | ERN1 (0.53) | ERN1KDM4EALDH1A1GAALMNA | |
| SCHEMBL12316453 | 0.84 | ERN1 (0.53) | ERN1KDM4EALDH1A1GAALMNA | |
| SCHEMBL11179253 | 0.81 | KDM4E (0.54) | ERN1KDM4EALDH1A1LMNACYP3A4 | |
| SCHEMBL1541991 | 0.80 | ERN1 (0.64) | ERN1KDM4EALDH1A1GAALMNA | |
| SCHEMBL29274101 | 0.76 | KDM4E (0.44) | KDM4EALDH1A1GAALMNAAKR1C4 | |
| SCHEMBL11519119 | 0.76 | ERN1 (0.47) | ERN1KDM4EALDH1A1GAALMNA | |
| SCHEMBL1423874 | 0.76 | FLT1 (0.55) | ALDH1A1LMNAKCNMA1 | |
| SCHEMBL257135 | 0.76 | LMNA (0.61) | ALDH1A1GAALMNAKCNMA1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050124664-A1 | Urea thiadiazole inhibitors of plasminogen activator inhibior-1 | BRISTOL-MYERS SQUIBB CO. | 2005-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124664-A1 | Urea thiadiazole inhibitors of plasminogen activator inhibior-1 | SERPINE1, SERPINC1, SERPINB1 | ERN1 856/4885KDM4E 4669/4885ALDH1A1 155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.