Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.48 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ELANE | P08246 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29191002 | 0.86 | POLB (0.51) | KMT2AMEN1HTTELANEALDH1A1 | |
| SCHEMBL6325084 | 0.82 | LMNA (0.58) | KMT2ASMN1; SMN2MEN1NOD2NOD1 | |
| SCHEMBL6326811 | 0.81 | MAPK1 (0.56) | KMT2ASMN1; SMN2MEN1ALDH1A1MAPT | |
| SCHEMBL4321608 | 0.80 | MAPT (0.58) | ARKMT2ASMN1; SMN2KCNJ1KCNH2 | |
| 4-Nitrobenzoic Acid Ethyl Ester SCHEMBL1500579 | 0.78 | KCNJ1 (0.68) | ARKMT2AKCNJ1KCNH2MEN1 | |
| 4-Nitrobenzoic Acid Ethyl Ester SCHEMBL27941051 | 0.76 | KCNJ1 (0.67) | ARKMT2AKCNJ1KCNH2MEN1 | |
| 4-Nitrobenzoic Acid Ethyl Ester SCHEMBL28242787 | 0.76 | KCNJ1 (0.67) | ARKMT2AKCNJ1KCNH2MEN1 | |
| 4-Nitrobenzoic Acid Ethyl Ester SCHEMBL21246856 | 0.76 | KCNJ1 (0.67) | ARKMT2AKCNJ1KCNH2MEN1 | |
| SCHEMBL23069579 | 0.75 | TSHR (0.48) | SMN1; SMN2ALDH1A1MAPTLMNA | |
| SCHEMBL28362521 | 0.74 | KCNJ1 (0.64) | ARKMT2AKCNJ1KCNH2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050124664-A1 | Urea thiadiazole inhibitors of plasminogen activator inhibior-1 | BRISTOL-MYERS SQUIBB CO. | 2005-06-09 | — | — | US | claimed |
| US-20050124664-A1 | Urea thiadiazole inhibitors of plasminogen activator inhibior-1 | BRISTOL-MYERS SQUIBB CO. | 2005-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124664-A1 | Urea thiadiazole inhibitors of plasminogen activator inhibior-1 | SERPINE1, SERPINC1, SERPINB1 | AR 913/4885KMT2A 4128/4885SMN1; SMN2 3158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.